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    Unc45a unc-45 myosin chaperone A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308759, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Unc45aprovided by RGD
    Official Full Name
    unc-45 myosin chaperone Aprovided by RGD
    Primary source
    RGD:1305357
    See related
    EnsemblRapid:ENSRNOG00000012357 AllianceGenome:RGD:1305357
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305357
    Summary
    Predicted to enable Hsp90 protein binding activity. Predicted to be involved in chaperone-mediated protein folding. Predicted to be located in Golgi apparatus; cytosol; and nuclear speck. Predicted to be active in cytoplasm. Orthologous to human UNC45A (unc-45 myosin chaperone A). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Adrenal (RPKM 81.5), Kidney (RPKM 63.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Unc45a in Genome Data Viewer
    Location:
    1q31
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (143691183..143705944, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (134281930..134296661, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (142118910..142135219, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA48 Neighboring gene protein regulator of cytokinesis 1 Neighboring gene RCC1 domain containing 1 Neighboring gene shisa like 3 Neighboring gene HD domain containing 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Unc45 activates Hsp90-dependent folding of the myosin motor domain. Liu L, et al. J Biol Chem, 2008 May 9. PMID 18326487, Free PMC Article
    2. Association of connexin43 with E3 ubiquitin ligase TRIM21 reveals a mechanism for gap junction phosphodegron control. Chen VC, et al. J Proteome Res, 2012 Dec 7. PMID 23106098
    3. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Guo Z, et al. Sci Signal, 2014 Dec 2. PMID 25468996, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC125248

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables Hsp90 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Hsp90 protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chaperone-mediated protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within chaperone-mediated protein folding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in muscle organ development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein unc-45 homolog A
    Names
    SMAP-1
    UNC-45A
    smooth muscle cell-associated protein 1
    unc-45 homolog A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037647.1 → NP_001032736.1  protein unc-45 homolog A

      Status: PROVISIONAL

      Source sequence(s)
      BC107919
      UniProtKB/Swiss-Prot
      Q32PZ3
      UniProtKB/TrEMBL
      A0A8I5ZTS5, A6JCA2
      Related
      ENSRNOP00000082238.1, ENSRNOT00000110547.2
      Conserved Domains (6) summary
      cd00020
      Location:684 → 803
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00006
      Location:21 → 49
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:92 → 125
      TPR_1; Tetratricopeptide repeat
      pfam11701
      Location:361 → 505
      UNC45-central; Myosin-binding striated muscle assembly central
      pfam13414
      Location:20 → 88
      TPR_11; TPR repeat
      sd00043
      Location:768 → 803
      ARM; armadillo repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      143691183..143705944 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006229432.5 → XP_006229494.1  protein unc-45 homolog A isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZTS5
      Related
      ENSRNOP00000017407.5, ENSRNOT00000017407.8
      Conserved Domains (6) summary
      cd00020
      Location:669 → 788
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00006
      Location:6 → 34
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:77 → 110
      TPR_1; Tetratricopeptide repeat
      pfam11701
      Location:346 → 490
      UNC45-central; Myosin-binding striated muscle assembly central
      pfam13414
      Location:5 → 73
      TPR_11; TPR repeat
      sd00043
      Location:753 → 788
      ARM; armadillo repeat [structural motif]

    2. XM_039112980.2 → XP_038968908.1  protein unc-45 homolog A isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZTS5
      Conserved Domains (1) summary
      pfam11701
      Location:216 → 360
      UNC45-central; Myosin-binding striated muscle assembly central
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q32PZ3.1 GenPept UniProtKB/Swiss-Prot:Q32PZ3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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