Naxd NAD(P)HX dehydratase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Naxdprovided by RGD
Official Full Name: NAD(P)HX dehydrataseprovided by RGD
Primary source: RGD:1562691
See related: EnsemblRapid:ENSRNOG00000015021 AllianceGenome:RGD:1562691
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Carkd; RGD1562691
Summary: Enables ATP-dependent NAD(P)H-hydrate dehydratase activity. Involved in metabolite repair. Predicted to be located in cytosol; endoplasmic reticulum; and mitochondrion. Orthologous to human NAXD (NAD(P)HX dehydratase). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Liver (RPKM 184.4), Kidney (RPKM 127.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16q12.5

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (84689776..84706256, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (77986148..78004200, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (83326228..83342711, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The human, mouse, and rat Carkd genes contain a first exon with two alternative 3' splice sites and two putative initiator ATG codons; the second exon also comprises a highly conserved ATG codon.
Title: Occurrence and subcellular distribution of the NADPHX repair system in mammals.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP-dependent NAD(P)H-hydrate dehydratase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP-dependent NAD(P)H-hydrate dehydratase activity	IDA Inferred from Direct Assay more info	PubMed
enables ATP-dependent NAD(P)H-hydrate dehydratase activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent NAD(P)H-hydrate dehydratase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in metabolite repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in metabolite repair	IDA Inferred from Direct Assay more info	PubMed
involved_in nicotinamide nucleotide metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ATP-dependent (S)-NAD(P)H-hydrate dehydratase

Names: ATP-dependent NAD(P)HX dehydratase; carbohydrate kinase domain containing; carbohydrate kinase domain-containing protein

NP_001101872.1

EC 4.2.1.93

XP_006253527.1

EC 4.2.1.93

XP_008769625.1

EC 4.2.1.93

XP_017455678.1

EC 4.2.1.93

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108402.1 → NP_001101872.1 ATP-dependent (S)-NAD(P)H-hydrate dehydratase

Status: PROVISIONAL

Source sequence(s)

CH473970

UniProtKB/Swiss-Prot

D4AAT7

UniProtKB/TrEMBL

A6IWP6

Conserved Domains (1) summary

cd01171
Location:49 → 316

YXKO-related; B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily.

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

84689776..84706256 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006253465.5 → XP_006253527.1 ATP-dependent (S)-NAD(P)H-hydrate dehydratase isoform X1

UniProtKB/TrEMBL

A0A8I5ZNB5, A6IWP7, D3ZLK9

Related

ENSRNOP00000060397.2, ENSRNOT00000065043.5

Conserved Domains (1) summary

cd01171
Location:87 → 354

YXKO-related; B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily.
XM_017600189.3 → XP_017455678.1 ATP-dependent (S)-NAD(P)H-hydrate dehydratase isoform X2

UniProtKB/Swiss-Prot

D4AAT7
XM_008771403.4 → XP_008769625.1 ATP-dependent (S)-NAD(P)H-hydrate dehydratase isoform X3

UniProtKB/TrEMBL

A0A8I6ACT3

Related

ENSRNOP00000091976.1, ENSRNOT00000100855.2

Conserved Domains (1) summary

cd01171
Location:49 → 237

YXKO-related; B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily.