Sirt5 sirtuin 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sirt5provided by RGD
Official Full Name: sirtuin 5provided by RGD
Primary source: RGD:1303285
See related: EnsemblRapid:ENSRNOG00000017866 AllianceGenome:RGD:1303285
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including NAD+ binding activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; and zinc ion binding activity. Involved in negative regulation of cardiac muscle cell apoptotic process and response to nutrient levels. Predicted to be located in mitochondrial inner membrane and mitochondrial intermembrane space. Predicted to be active in cytosol; mitochondrial matrix; and nucleus. Orthologous to human SIRT5 (sirtuin 5). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Heart (RPKM 365.5), Brain (RPKM 277.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17p14

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (21515982..21543529, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (21310028..21337137, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (23986710..24013854)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SIRT5 Regulates Ferroptosis through the Nrf2/HO-1 Signaling Axis to Participate in Ischemia-Reperfusion Injury in Ischemic Stroke.
Title: SIRT5 Regulates Ferroptosis through the Nrf2/HO-1 Signaling Axis to Participate in Ischemia-Reperfusion Injury in Ischemic Stroke.
SIRT5-related desuccinylation modification of AIFM1 protects against compression-induced intervertebral disc degeneration by regulating mitochondrial homeostasis.
Title: SIRT5-related desuccinylation modification of AIFM1 protects against compression-induced intervertebral disc degeneration by regulating mitochondrial homeostasis.
The possible role of sirtuin 5 in the pathogenesis of apical periodontitis.
Title: The possible role of sirtuin 5 in the pathogenesis of apical periodontitis.
Sirtuin 5 deficiency increases disease severity in rats with adjuvant-induced arthritis.
Title: Sirtuin 5 deficiency increases disease severity in rats with adjuvant-induced arthritis.
Both diabetic rats and mice demonstrated significantly weakened SIRT5 expression in the pancreas, compared to wild-type animals, implying a possible correlation between SIRT5 and pancreatic beta cell function.
Title: Sirtuin 5 overexpression attenuates glucolipotoxicity-induced pancreatic β cells apoptosis and dysfunction.
Caloric restriction (CR) retarded declines in cognitive ability and enhanced the expression of both SIRT1 and SIRT5 proteins in the cerebral tissue of CR rats compared with AL rats
Title: SIRT1 and SIRT5 activity expression and behavioral responses to calorie restriction.
Alcohol decreases mitochondrial SIRT5 level.
Title: Alcohol alters hepatic FoxO1, p53, and mitochondrial SIRT5 deacetylation function.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables NAD+ binding	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+ binding	ISO Inferred from Sequence Orthology more info
enables NAD+ binding	ISS Inferred from Sequence or Structural Similarity more info
enables NAD-dependent protein lysine deacetylase activity	IEA Inferred from Electronic Annotation more info
enables histone deacetylase activity, NAD-dependent	IBA Inferred from Biological aspect of Ancestor more info
enables protein-glutaryllysine deglutarylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-glutaryllysine deglutarylase activity	ISO Inferred from Sequence Orthology more info
enables protein-malonyllysine demalonylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-malonyllysine demalonylase activity	ISO Inferred from Sequence Orthology more info
enables protein-malonyllysine demalonylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein-succinyllysine desuccinylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-succinyllysine desuccinylase activity	ISO Inferred from Sequence Orthology more info
enables protein-succinyllysine desuccinylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in negative regulation of cardiac muscle cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-lysine demalonylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-lysine demalonylation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within peptidyl-lysine desuccinylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-lysine desuccinylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-lysine desuccinylation	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in protein deacetylation	ISO Inferred from Sequence Orthology more info
involved_in protein deacetylation	ISO Inferred from Sequence Orthology more info
NOT involved_in protein deacetylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein deglutarylation	ISO Inferred from Sequence Orthology more info
involved_in protein demalonylation	ISO Inferred from Sequence Orthology more info
involved_in protein demalonylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein desuccinylation	ISO Inferred from Sequence Orthology more info
involved_in protein desuccinylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of ketone biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of ketone biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of succinate dehydrogenase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to ischemia	ISO Inferred from Sequence Orthology more info
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial intermembrane space	ISO Inferred from Sequence Orthology more info
located_in mitochondrial intermembrane space	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: NAD-dependent protein deacylase sirtuin-5, mitochondrial

Names: NAD-dependent deacetylase sirtuin-5; NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial; SIR2-like protein 5; regulatory protein SIR2 homolog 5

NP_001004256.1

EC 2.3.1.-

EC 3.5.1.-

XP_006253863.1

EC 2.3.1.-

EC 3.5.1.-

XP_006253864.1

EC 2.3.1.-

EC 3.5.1.-

XP_006253865.1

EC 2.3.1.-

EC 3.5.1.-

XP_006253866.1

EC 2.3.1.-

EC 3.5.1.-

XP_038951601.1

EC 2.3.1.-

EC 3.5.1.-

XP_063132446.1

EC 2.3.1.-

EC 3.5.1.-

XP_063132447.1

EC 2.3.1.-

EC 3.5.1.-

XP_063132448.1

EC 2.3.1.-

EC 3.5.1.-

XP_063132449.1

EC 2.3.1.-

EC 3.5.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004256.1 → NP_001004256.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial

Status: PROVISIONAL

Source sequence(s)

BC078958

UniProtKB/Swiss-Prot

Q68FX9

UniProtKB/TrEMBL

A6J749

Related

ENSRNOP00000024067.4, ENSRNOT00000024066.7

Conserved Domains (1) summary

cd01412
Location:51 → 301

SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

21515982..21543529 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006253801.3 → XP_006253863.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1

UniProtKB/Swiss-Prot

Q68FX9

UniProtKB/TrEMBL

A6J749

Conserved Domains (1) summary

cd01412
Location:51 → 301

SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...
XM_006253802.3 → XP_006253864.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1

UniProtKB/Swiss-Prot

Q68FX9

UniProtKB/TrEMBL

A6J749

Conserved Domains (1) summary

cd01412
Location:51 → 301

SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...
XM_039095673.2 → XP_038951601.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1

UniProtKB/Swiss-Prot

Q68FX9

UniProtKB/TrEMBL

A6J749

Conserved Domains (1) summary

cd01412
Location:51 → 301

SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...
XM_006253803.5 → XP_006253865.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1

UniProtKB/Swiss-Prot

Q68FX9

UniProtKB/TrEMBL

A6J749

Conserved Domains (1) summary

cd01412
Location:51 → 301

SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...
XM_006253804.5 → XP_006253866.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1

UniProtKB/Swiss-Prot

Q68FX9

UniProtKB/TrEMBL

A6J749

Conserved Domains (1) summary

cd01412
Location:51 → 301

SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...
XM_063276376.1 → XP_063132446.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X2
XM_063276377.1 → XP_063132447.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X2
XM_063276378.1 → XP_063132448.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X2
XM_063276379.1 → XP_063132449.1 NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X2