U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Slc9a6 solute carrier family 9 member A6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 302863, updated on 4-Jan-2025

    Summary

    Official Symbol
    Slc9a6provided by RGD
    Official Full Name
    solute carrier family 9 member A6provided by RGD
    Primary source
    RGD:1563582
    See related
    EnsemblRapid:ENSRNOG00000000879 AllianceGenome:RGD:1563582
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    NHE-6; RGD1563582
    Summary
    Predicted to enable identical protein binding activity; potassium:proton antiporter activity; and sodium:proton antiporter activity. Involved in glial cell activation and regulation of synaptic vesicle lumen acidification. Is active in presynapse. Human ortholog(s) of this gene implicated in Christianson syndrome. Orthologous to human SLC9A6 (solute carrier family 9 member A6). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Brain (RPKM 158.8), Lung (RPKM 95.1) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Slc9a6 in Genome Data Viewer
    Location:
    Xq36
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (139468045..139524111)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (134430677..134486747)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (158979081..159045019)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene cancer/testis antigen family 45 member A9 Neighboring gene membrane magnesium transporter 1 Neighboring gene basic transcription factor 3, pseudogene 4 Neighboring gene U6 spliceosomal RNA Neighboring gene four and a half LIM domains 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding  
    enables potassium:proton antiporter activity  
    enables potassium:proton antiporter activity  
    enables sodium:proton antiporter activity  
    enables sodium:proton antiporter activity  
    Process Evidence Code Pubs
    acts_upstream_of_or_within axon extension  
    acts_upstream_of_or_within brain-derived neurotrophic factor receptor signaling pathway  
    acts_upstream_of_or_within dendrite extension  
    acts_upstream_of_or_within dendritic spine development  
    involved_in establishment of cell polarity  
    involved_in establishment of cell polarity  
    involved_in glial cell activation PubMed 
    acts_upstream_of_or_within neuron projection morphogenesis  
    involved_in potassium ion transmembrane transport  
    acts_upstream_of_or_within proton transmembrane transport  
    involved_in regulation of intracellular pH  
    involved_in regulation of intracellular pH  
    acts_upstream_of_or_within regulation of neurotrophin TRK receptor signaling pathway  
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels  
    involved_in regulation of synaptic vesicle lumen acidification PubMed 
    involved_in regulation of synaptic vesicle lumen acidification PubMed 
    involved_in regulation of synaptic vesicle lumen acidification PubMed 
    involved_in sodium ion import across plasma membrane  
    acts_upstream_of_or_within synapse organization  
    Items 1 - 20 of 25
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse  
    located_in axon terminus  
    located_in axonal spine  
    located_in cytoplasmic vesicle  
    located_in dendrite  
    located_in early endosome  
    located_in early endosome membrane  
    located_in early endosome membrane  
    located_in endoplasmic reticulum membrane  
    located_in endosome  
    is_active_in glutamatergic synapse  
    located_in intracellular membrane-bounded organelle  
    located_in late endosome  
    located_in late endosome membrane  
    NOT located_in mitochondrion  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    is_active_in presynapse PubMed 
    is_active_in presynapse PubMed 
    is_active_in recycling endosome  
    located_in recycling endosome  
    located_in recycling endosome membrane  
    located_in recycling endosome membrane  
    located_in synapse  
    Items 1 - 20 of 25

    General protein information

    Preferred Names
    sodium/hydrogen exchanger 6
    Names
    Na(+)/H(+) exchanger 6
    solute carrier family 9 (sodium/hydrogen exchanger), member 6
    solute carrier family 9 member 6
    solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419592.1NP_001406521.1  sodium/hydrogen exchanger 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A6KSN8
      Related
      ENSRNOP00000104438.1, ENSRNOT00000122635.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      139468045..139524111
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039100496.2XP_038956424.1  sodium/hydrogen exchanger 6 isoform X2

      UniProtKB/TrEMBL
      A6KSN8
      Conserved Domains (1) summary
      TIGR00840
      Location:94540
      b_cpa1; sodium/hydrogen exchanger 3
    2. XM_217630.11XP_217630.3  sodium/hydrogen exchanger 6 isoform X1

      See identical proteins and their annotated locations for XP_217630.3

      UniProtKB/TrEMBL
      A6KSN8
      Related
      ENSRNOP00000060014.4, ENSRNOT00000066809.5
      Conserved Domains (1) summary
      pfam00999
      Location:177534
      Na_H_Exchanger; Sodium/hydrogen exchanger family
    Loading
    External link. Please review our privacy policy.