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    Akip1 A-kinase interacting protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361624, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Akip1provided by RGD
    Official Full Name
    A-kinase interacting protein 1provided by RGD
    Primary source
    RGD:1306959
    See related
    EnsemblRapid:ENSRNOG00000013744 AllianceGenome:RGD:1306959
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306959
    Summary
    Predicted to be involved in regulation of non-canonical NF-kappaB signal transduction. Predicted to act upstream of or within substrate adhesion-dependent cell spreading. Predicted to be active in nucleoplasm. Orthologous to human AKIP1 (A-kinase interacting protein 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Testes (RPKM 64.0), Lung (RPKM 49.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Akip1 in Genome Data Viewer
    Location:
    1q33
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (173169520..173178445)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (163734730..163743648)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (174330628..174339494)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene DENN domain containing 2B Neighboring gene uncharacterized LOC134483772 Neighboring gene charged multivesicular body protein 1b-like Neighboring gene similar to human chromosome 11 open reading frame 16 Neighboring gene achaete-scute family bHLH transcription factor 3 Neighboring gene TMEM9 domain family, member B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. AKIP1 expression modulates mitochondrial function in rat neonatal cardiomyocytes. Yu H, et al. PLoS One, 2013. PMID 24236204, Free PMC Article
    2. AKIP1, a cardiac hypertrophy induced protein that stimulates cardiomyocyte growth via the Akt pathway. Yu H, et al. Int J Mol Sci, 2013 Oct 28. PMID 24169435, Free PMC Article
    3. A kinase interacting protein (AKIP1) is a key regulator of cardiac stress. Sastri M, et al. Proc Natl Acad Sci U S A, 2013 Jan 29. PMID 23319652, Free PMC Article
    4. Breast cancer-associated gene 3 (BCA3) is a novel Rac1-interacting protein. Yu KP, et al. J Bone Miner Res, 2007 Apr. PMID 17227220
    5. MiR-320 regulates cardiomyocyte apoptosis induced by ischemia-reperfusion injury by targeting AKIP1. Tian ZQ, et al. Cell Mol Biol Lett, 2018. PMID 30181740, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. miR-320 plays an important role in regulating cardiomyocyte apoptosis induced by ischemia-reperfusion injury by targeting AKIP1 and inducing the mitochondrial apoptotic pathway.
      Title: MiR-320 regulates cardiomyocyte apoptosis induced by ischemia-reperfusion injury by targeting AKIP1.
    2. AKIP1 expression modulates mitochondrial function in rat neonatal cardiomyocytes.
      Title: AKIP1 expression modulates mitochondrial function in rat neonatal cardiomyocytes.
    3. our results show that AKIP1 is induced in hypertrophic hearts and can stimulate adaptive cardiomyocyte growth, which involves Akt signaling
      Title: AKIP1, a cardiac hypertrophy induced protein that stimulates cardiomyocyte growth via the Akt pathway.
    4. Data indicate A-kinase interacting protein 1 (AKIP1) as a critical molecular regulator and a therapeutic control point for stress adaptation in the heart.
      Title: A kinase interacting protein (AKIP1) is a key regulator of cardiac stress.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in regulation of non-canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    A-kinase-interacting protein 1
    Names
    A kinase (PRKA) interacting protein 1
    proline-rich protein BCA3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108497.1 → NP_001101967.1  A-kinase-interacting protein 1

      Status: PROVISIONAL

      Source sequence(s)
      CH473956
      UniProtKB/TrEMBL
      A0A8I6GIH5, A6I7X8, D3ZV70
      Related
      ENSRNOP00000018497.4, ENSRNOT00000018497.7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      173169520..173178445
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006229987.4 → XP_006230049.1  A-kinase-interacting protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GIH5, A6I7X8, D3ZV70

    2. XM_063267397.1 → XP_063123467.1  A-kinase-interacting protein 1 isoform X13

    3. XM_063267408.1 → XP_063123478.1  A-kinase-interacting protein 1 isoform X14

    4. XM_006229990.4 → XP_006230052.1  A-kinase-interacting protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6GIH5, A6I7X9

    5. XM_063267390.1 → XP_063123460.1  A-kinase-interacting protein 1 isoform X11

      UniProtKB/TrEMBL
      A6I7Y4, A6I7Y5

    6. XM_039082670.2 → XP_038938598.1  A-kinase-interacting protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A8I6GIH5, A6I7Y2

    7. XM_039082660.2 → XP_038938588.1  A-kinase-interacting protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I6GIH5
      Related
      ENSRNOP00000089931.2, ENSRNOT00000093972.2

    8. XM_063267383.1 → XP_063123453.1  A-kinase-interacting protein 1 isoform X9

      UniProtKB/TrEMBL
      A6I7Y4

    9. XM_006229989.4 → XP_006230051.1  A-kinase-interacting protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GIH5

    10. XM_063267374.1 → XP_063123444.1  A-kinase-interacting protein 1 isoform X5

      UniProtKB/TrEMBL
      A0A8I6GIH5

    11. XM_063267362.1 → XP_063123432.1  A-kinase-interacting protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GIH5

    12. XM_063267378.1 → XP_063123448.1  A-kinase-interacting protein 1 isoform X8

    13. XM_006229988.4 → XP_006230050.1  A-kinase-interacting protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GIH5, A6I7X8, D3ZV70

    14. XM_063267377.1 → XP_063123447.1  A-kinase-interacting protein 1 isoform X7

      UniProtKB/TrEMBL
      A0A8I6GIH5, A6I7Y1

    15. XM_063267388.1 → XP_063123458.1  A-kinase-interacting protein 1 isoform X10

    16. XM_039082668.2 → XP_038938596.1  A-kinase-interacting protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I6GIH5

    17. XM_039082652.2 → XP_038938580.1  A-kinase-interacting protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6GIH5, A6I7X9

    18. XM_039082689.2 → XP_038938617.1  A-kinase-interacting protein 1 isoform X12

      UniProtKB/TrEMBL
      A6I7Y4
    Nucleotide Protein Strain
    Heading Accession and Version

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