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    Npr3 natriuretic peptide receptor 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25339, updated on 4-Jan-2025

    Summary

    Official Symbol
    Npr3provided by RGD
    Official Full Name
    natriuretic peptide receptor 3provided by RGD
    Primary source
    RGD:3196
    See related
    EnsemblRapid:ENSRNOG00000019184 AllianceGenome:RGD:3196
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    NPRC; ANP-CR
    Summary
    Enables identical protein binding activity; peptide hormone binding activity; and peptide receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; negative regulation of adenylate cyclase activity; and positive regulation of nitric-oxide synthase activity. Predicted to be located in plasma membrane. Predicted to be part of protein-containing complex. Biomarker of diabetic retinopathy. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human NPR3 (natriuretic peptide receptor 3). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Heart (RPKM 153.4), Lung (RPKM 134.4) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Npr3 in Genome Data Viewer
    Location:
    2q16
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (62592557..62660497, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (60865483..60933432, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (61883946..61950291, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene diazepam binding inhibitor, acyl-CoA binding protein, pseudogene 2 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene uncharacterized LOC120101085 Neighboring gene SUB1 regulator of transcription

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity PubMed 
    enables chloride ion binding  
    enables chloride ion binding  
    enables hormone binding  
    enables identical protein binding PubMed 
    enables natriuretic peptide receptor activity  
    enables natriuretic peptide receptor activity PubMed 
    enables natriuretic peptide receptor activity  
    enables natriuretic peptide receptor activity PubMed 
    enables natriuretic peptide receptor activity  
    enables natriuretic peptide receptor activity  
    enables peptide binding  
    enables peptide binding  
    enables peptide hormone binding  
    enables peptide hormone binding PubMed 
    enables peptide hormone binding  
    enables peptide hormone binding  
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    Items 1 - 25 of 33
    Process Evidence Code Pubs
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway PubMed 
    involved_in angiogenesis  
    involved_in angiogenesis  
    involved_in blood vessel remodeling  
    involved_in blood vessel remodeling  
    involved_in negative regulation of adenylate cyclase activity PubMed 
    involved_in negative regulation of cold-induced thermogenesis  
    involved_in negative regulation of cold-induced thermogenesis  
    involved_in negative regulation of cold-induced thermogenesis PubMed 
    involved_in negative regulation of smooth muscle cell proliferation PubMed 
    involved_in osteoclast proliferation  
    involved_in osteoclast proliferation  
    involved_in osteoclast proliferation  
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway PubMed 
    involved_in positive regulation of nitric-oxide synthase activity PubMed 
    involved_in positive regulation of pancreatic juice secretion PubMed 
    involved_in positive regulation of urine volume  
    involved_in positive regulation of urine volume  
    involved_in positive regulation of urine volume  
    involved_in regulation of blood pressure  
    involved_in regulation of blood pressure PubMed 
    involved_in regulation of blood pressure  
    involved_in regulation of blood pressure  
    involved_in regulation of osteoblast proliferation  
    involved_in regulation of osteoblast proliferation  
    involved_in regulation of osteoblast proliferation  
    involved_in response to ischemia  
    involved_in response to ischemia  
    involved_in signal transduction  
    involved_in skeletal system development  
    involved_in skeletal system development  
    involved_in skeletal system development  
    involved_in vasodilation PubMed 
    Items 1 - 25 of 33
    Component Evidence Code Pubs
    located_in membrane  
    located_in plasma membrane PubMed 
    part_of protein-containing complex  
    part_of protein-containing complex  

    General protein information

    Preferred Names
    atrial natriuretic peptide receptor 3
    Names
    ANP-C
    ANPR-C
    ANPRC
    Atrial natriuretic peptide clearence receptor 3
    NPR-C
    atrial natriuretic peptide C-type receptor
    atrial natriuretic peptide clearance receptor
    atrial natriuretic peptide receptor type C
    natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012868.1NP_037000.1  atrial natriuretic peptide receptor 3 precursor

      Status: PROVISIONAL

      Source sequence(s)
      L27339
      UniProtKB/Swiss-Prot
      P41740, Q64156
      UniProtKB/TrEMBL
      A6KJR1
      Conserved Domains (2) summary
      cd06386
      Location:49440
      PBP1_NPR_C_like; Ligand-binding domain of type C natriuretic peptide receptor
      cl25995
      Location:466501
      TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      62592557..62660497 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039101782.2XP_038957710.1  atrial natriuretic peptide receptor 3 isoform X2

      UniProtKB/TrEMBL
      A6KJR3
      Conserved Domains (2) summary
      cd12841
      Location:217248
      TM_EphA1; Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase
      cl10011
      Location:1187
      Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
    2. XM_006232045.5XP_006232107.2  atrial natriuretic peptide receptor 3 isoform X1

      UniProtKB/TrEMBL
      A0A8L2QFC4
      Related
      ENSRNOP00000025966.5, ENSRNOT00000025966.7
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