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    Zfp52 zinc finger protein 52 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361487, updated on 4-Jan-2025

    Summary

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    Symbol
    Zfp52provided by RGD
    Full Name
    zinc finger protein 52provided by RGD
    Primary source
    RGD:1359149
    See related
    EnsemblRapid:ENSRNOG00000042826 AllianceGenome:RGD:1359149
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Testes (RPKM 121.4), Thymus (RPKM 45.1) and 9 other tissues See more
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    Genomic context

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    See Zfp52 in Genome Data Viewer
    Location:
    1q12
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (69998534..70036017)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (61326960..61363105)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (61389594..61426327)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 54-like Neighboring gene transfer RNA arginine (anticodon CCU) 1 Neighboring gene ribonuclease H2, subunit B, pseudogene 1 Neighboring gene zinc finger protein 53 Neighboring gene uncharacterized LOC102547319 Neighboring gene uncharacterized LOC134482874 Neighboring gene zinc finger protein 948 Neighboring gene zinc finger protein 420-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 52
    Names
    zinc finger protein 695-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014158.1 → NP_001014180.1  zinc finger protein 52

      See identical proteins and their annotated locations for NP_001014180.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085827
      UniProtKB/TrEMBL
      Q5U2X3
      Conserved Domains (6) summary
      COG5048
      Location:329 → 702
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:241 → 324
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:667 → 687
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:443 → 463
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:44 → 84
      KRAB; KRAB box
      pfam13465
      Location:707 → 730
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      69998534..70036017
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266251.1 → XP_063122321.1  zinc finger protein 52 isoform X1

      UniProtKB/TrEMBL
      Q5U2X3
      Related
      ENSRNOP00000044868.3, ENSRNOT00000050119.7

    2. XM_063266237.1 → XP_063122307.1  zinc finger protein 52 isoform X1

      UniProtKB/TrEMBL
      Q5U2X3

    3. XM_017589343.3 → XP_017444832.1  zinc finger protein 52 isoform X1

      UniProtKB/TrEMBL
      Q5U2X3
      Conserved Domains (6) summary
      COG5048
      Location:329 → 702
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:241 → 324
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:667 → 687
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:443 → 463
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:44 → 84
      KRAB; KRAB box
      pfam13465
      Location:707 → 730
      zf-H2C2_2; Zinc-finger double domain

    4. XM_039081352.2 → XP_038937280.1  zinc finger protein 52 isoform X2

      Conserved Domains (6) summary
      COG5048
      Location:297 → 670
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:209 → 292
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:635 → 655
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:411 → 431
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:12 → 52
      KRAB; KRAB box
      pfam13465
      Location:675 → 698
      zf-H2C2_2; Zinc-finger double domain

    5. XM_039081334.2 → XP_038937262.1  zinc finger protein 52 isoform X1

      UniProtKB/TrEMBL
      Q5U2X3
      Conserved Domains (6) summary
      COG5048
      Location:329 → 702
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:241 → 324
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:667 → 687
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:443 → 463
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:44 → 84
      KRAB; KRAB box
      pfam13465
      Location:707 → 730
      zf-H2C2_2; Zinc-finger double domain

    6. XM_039081333.2 → XP_038937261.1  zinc finger protein 52 isoform X1

      UniProtKB/TrEMBL
      Q5U2X3
      Conserved Domains (6) summary
      COG5048
      Location:329 → 702
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:241 → 324
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:667 → 687
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:443 → 463
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:44 → 84
      KRAB; KRAB box
      pfam13465
      Location:707 → 730
      zf-H2C2_2; Zinc-finger double domain

    7. XM_039081349.2 → XP_038937277.1  zinc finger protein 52 isoform X1

      UniProtKB/TrEMBL
      Q5U2X3
      Conserved Domains (6) summary
      COG5048
      Location:329 → 702
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:241 → 324
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:667 → 687
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:443 → 463
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:44 → 84
      KRAB; KRAB box
      pfam13465
      Location:707 → 730
      zf-H2C2_2; Zinc-finger double domain

    8. XM_017589345.3 → XP_017444834.1  zinc finger protein 52 isoform X1

      UniProtKB/TrEMBL
      Q5U2X3
      Conserved Domains (6) summary
      COG5048
      Location:329 → 702
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:241 → 324
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:667 → 687
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:443 → 463
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:44 → 84
      KRAB; KRAB box
      pfam13465
      Location:707 → 730
      zf-H2C2_2; Zinc-finger double domain

    9. XM_039081361.2 → XP_038937289.1  zinc finger protein 52 isoform X2

      Related
      ENSRNOP00000094976.2, ENSRNOT00000118803.2
      Conserved Domains (6) summary
      COG5048
      Location:297 → 670
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:209 → 292
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:635 → 655
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:411 → 431
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:12 → 52
      KRAB; KRAB box
      pfam13465
      Location:675 → 698
      zf-H2C2_2; Zinc-finger double domain

    10. XM_063266243.1 → XP_063122313.1  zinc finger protein 52 isoform X1

      UniProtKB/TrEMBL
      Q5U2X3
    Nucleotide Protein Strain
    Heading Accession and Version

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