Prss12 serine protease 12 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Prss12provided by RGD
Official Full Name: serine protease 12provided by RGD
Primary source: RGD:69238
See related: EnsemblRapid:ENSRNOG00000015353 AllianceGenome:RGD:69238
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nt
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in exocytosis. Predicted to act upstream of or within zymogen activation. Predicted to be located in several cellular components, including axon; cytoplasmic vesicle; and synapse. Predicted to be active in several cellular components, including Schaffer collateral - CA1 synapse; glutamatergic synapse; and synaptic cleft. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 1 and intellectual disability. Orthologous to human PRSS12 (serine protease 12). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 49.4), Lung (RPKM 38.7) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q42

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (214308695..214368679)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (211624134..211684126)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (227657983..227717884)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NMR structure of neurotrypsin kringle domain
Title: NMR solution structure of the neurotrypsin Kringle domain.

Submit: New GeneRIF Correction

General gene information

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Markers

D2Rat242 (e-PCR), detects polymorphism
- UniSTS:227389

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables peptidase activity	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in exocytosis	ISO Inferred from Sequence Orthology more info
involved_in exocytosis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within proteolysis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within zymogen activation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axon	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in presynapse	ISO Inferred from Sequence Orthology more info
located_in synapse	ISO Inferred from Sequence Orthology more info
is_active_in synaptic cleft	IBA Inferred from Biological aspect of Ancestor more info
located_in synaptic cleft	ISO Inferred from Sequence Orthology more info
is_active_in terminal bouton	IBA Inferred from Biological aspect of Ancestor more info
located_in terminal bouton	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: neurotrypsin

Names: peptidase, serine, 12 (neurotrypsin, motopsin); protease, serine 12; protease, serine, 12 neurotrypsin (motopsin)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053504.1 → NP_445956.1 neurotrypsin precursor

See identical proteins and their annotated locations for NP_445956.1

Status: PROVISIONAL

Source sequence(s)

AJ311671

UniProtKB/Swiss-Prot

G3V801, Q99JC8

Related

ENSRNOP00000021116.3, ENSRNOT00000021116.5

Conserved Domains (5) summary

smart00020
Location:516 → 755

Tryp_SPc; Trypsin-like serine protease

smart00130
Location:83 → 159

KR; Kringle domain

smart00202
Location:166 → 265

SR; Scavenger receptor Cys-rich

cd00190
Location:517 → 758

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam00530
Location:171 → 266

SRCR; Scavenger receptor cysteine-rich domain