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    Pdcd1lg2 programmed cell death 1 ligand 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309304, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pdcd1lg2provided by RGD
    Official Full Name
    programmed cell death 1 ligand 2provided by RGD
    Primary source
    RGD:1306403
    See related
    EnsemblRapid:ENSRNOG00000016136 AllianceGenome:RGD:1306403
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PD-L2
    Summary
    Predicted to be involved in several processes, including cellular response to lipopolysaccharide; negative regulation of cytokine production; and regulation of T cell activation. Predicted to be active in external side of plasma membrane. Orthologous to human PDCD1LG2 (programmed cell death 1 ligand 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 52.1), Heart (RPKM 43.1) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pdcd1lg2 in Genome Data Viewer
    Location:
    1q52
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (236572497..236637490)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (227158941..227223938)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (247562202..247629279)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene plasminogen receptor with a C-terminal lysine Neighboring gene CD274 molecule Neighboring gene uncharacterized LOC134485219 Neighboring gene nucleolar pre-rRNA processing protein NIP7, pseudogene 2 Neighboring gene uncharacterized LOC134485218 Neighboring gene uncharacterized LOC134485217 Neighboring gene RIC1 homolog, RAB6A GEF complex partner 1 Neighboring gene endoplasmic reticulum metallopeptidase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Aberrant PD-1 ligand expression contributes to the myocardial inflammatory injury caused by Coxsackievirus B infection. Wang T, et al. Antiviral Res, 2019 Jun. PMID 30904424
    2. Dexmedetomidine Mitigates Microglia-Mediated Neuroinflammation through Upregulation of Programmed Cell Death Protein 1 in a Rat Spinal Cord Injury Model. He H, et al. J Neurotrauma, 2018 Nov 1. PMID 29665726
    3. Lymphocyte subset expression and serum concentrations of PD-1/PD-L1 in sepsis - pilot study. Wilson JK, et al. Crit Care, 2018 Apr 17. PMID 29661225, Free PMC Article
    4. Inhibiting the programmed death 1 pathway rescues Mycobacterium tuberculosis-specific interferon γ-producing T cells from apoptosis in patients with pulmonary tuberculosis. Singh A, et al. J Infect Dis, 2013 Aug 15. PMID 23661793
    5. PD-L1 and PD-L2 have distinct roles in regulating host immunity to cutaneous leishmaniasis. Liang SC, et al. Eur J Immunol, 2006 Jan. PMID 16358363

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in T cell costimulation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to lipopolysaccharide IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of T cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of activated T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of interleukin-10 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of type II interferon production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of T cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    programmed cell death 1 ligand 2
    Names
    PD-1 ligand 2
    PDCD1 ligand 2
    programmed death ligand 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107582.4 → NP_001101052.2  programmed cell death 1 ligand 2 precursor

      See identical proteins and their annotated locations for NP_001101052.2

      Status: INFERRED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6I0W5, D4AAV6
      Related
      ENSRNOP00000021615.6, ENSRNOT00000021614.8
      Conserved Domains (2) summary
      smart00410
      Location:28 → 119
      IG_like; Immunoglobulin like
      cl11960
      Location:137 → 193
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      236572497..236637490
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006231209.5 → XP_006231271.1  programmed cell death 1 ligand 2 isoform X1

      See identical proteins and their annotated locations for XP_006231271.1

      UniProtKB/TrEMBL
      A6I0W5, D4AAV6
      Conserved Domains (2) summary
      smart00410
      Location:28 → 119
      IG_like; Immunoglobulin like
      cl11960
      Location:137 → 193
      Ig; Immunoglobulin domain

    2. XM_039079984.2 → XP_038935912.1  programmed cell death 1 ligand 2 isoform X2

      Conserved Domains (2) summary
      cd00096
      Location:25 → 30
      Ig; Ig strand A [structural motif]
      cl11960
      Location:25 → 106
      Ig; Immunoglobulin domain

    3. XM_039079989.2 → XP_038935917.1  programmed cell death 1 ligand 2 isoform X3

      Conserved Domains (2) summary
      cd00096
      Location:19 → 24
      Ig; Ig strand A [structural motif]
      cl11960
      Location:19 → 100
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version

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