Ap4m1 adaptor related protein complex 4 subunit mu 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ap4m1provided by RGD
Official Full Name: adaptor related protein complex 4 subunit mu 1provided by RGD
Primary source: RGD:1310233
See related: EnsemblRapid:ENSRNOG00000001353 AllianceGenome:RGD:1310233
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable protein domain specific binding activity. Predicted to be involved in several processes, including post-Golgi vesicle-mediated transport; protein localization to basolateral plasma membrane; and protein targeting to lysosome. Predicted to be located in early endosome. Predicted to be part of AP-4 adaptor complex. Predicted to be active in cytoplasmic vesicle and trans-Golgi network. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 50. Orthologous to human AP4M1 (adaptor related protein complex 4 subunit mu 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 97.2), Adrenal (RPKM 88.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q11

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (22163474..22171734)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (17049766..17055954)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (19314222..19320339)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AP4M1 is not only down-regulated at both the mRNA and protein levels, but also redistributed from dendrites to axons in oxygen-glucose deprived hippocampal neurons.
Title: AP4M1 is abnormally expressed in oxygen-glucose deprived hippocampal neurons.

Submit: New GeneRIF Correction

General gene information

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Markers

RH137179 (e-PCR)
- UniSTS:219267

Ap4m1 (e-PCR), detects polymorphism
- UniSTS:528061

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Golgi to endosome transport	ISO Inferred from Sequence Orthology more info
involved_in Golgi to endosome transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in Golgi to lysosome transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in Golgi to lysosome transport	ISO Inferred from Sequence Orthology more info
involved_in Golgi to lysosome transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in autophagosome assembly	ISO Inferred from Sequence Orthology more info
involved_in autophagosome assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in intracellular protein transport	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization	ISO Inferred from Sequence Orthology more info
involved_in protein localization	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in protein localization to basolateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein targeting	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein targeting	ISO Inferred from Sequence Orthology more info
involved_in protein targeting	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein targeting to lysosome	ISO Inferred from Sequence Orthology more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of AP-4 adaptor complex	ISO Inferred from Sequence Orthology more info
part_of AP-4 adaptor complex	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
part_of clathrin adaptor complex	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in trans-Golgi network	IBA Inferred from Biological aspect of Ancestor more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: AP-4 complex subunit mu-1

Names: AP-4 adapter complex mu subunit; AP-4 adaptor complex mu subunit; adapter-related protein complex 4 mu-1 subunit; adapter-related protein complex 4 subunit mu-1; adaptor-related protein complex 4, mu 1 subunit; adaptor-related protein complex AP-4, mu 1; mu subunit of AP-4; mu-ARP2; mu-adaptin-related protein 2; mu4; mu4-adaptin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037977.3 → NP_001033066.1 AP-4 complex subunit mu-1 isoform 1

See identical proteins and their annotated locations for NP_001033066.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

UniProtKB/Swiss-Prot

Q2PWT8

UniProtKB/TrEMBL

A0A8I6B231, A6KST1

Conserved Domains (2) summary

cl02092
Location:1 → 130

Clat_adaptor_s; Clathrin adaptor complex small chain

cd09253
Location:175 → 453

AP-4_Mu4_Cterm; C-terminal domain of medium Mu4 subunit in adaptor protein (AP) complex AP-4
NM_001413271.2 → NP_001400200.1 AP-4 complex subunit mu-1 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

22163474..22171734

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063271278.1 → XP_063127348.1 AP-4 complex subunit mu-1 isoform X3

UniProtKB/TrEMBL

A0A8I6B231
XM_006249008.4 → XP_006249070.1 AP-4 complex subunit mu-1 isoform X1

UniProtKB/TrEMBL

A0A8I6B231

Related

ENSRNOP00000001827.3, ENSRNOT00000001827.6

Conserved Domains (2) summary

cl02092
Location:1 → 130

Clat_adaptor_s; Clathrin adaptor complex small chain

cd09253
Location:175 → 457

AP-4_Mu4_Cterm; C-terminal domain of medium Mu4 subunit in adaptor protein (AP) complex AP-4
XM_039089411.2 → XP_038945339.1 AP-4 complex subunit mu-1 isoform X2

Conserved Domains (1) summary

cd09253
Location:47 → 329

AP-4_Mu4_Cterm; C-terminal domain of medium Mu4 subunit in adaptor protein (AP) complex AP-4