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    Trim52 tripartite motif-containing 52 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290458, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Trim52provided by RGD
    Official Full Name
    tripartite motif-containing 52provided by RGD
    Primary source
    RGD:1565615
    See related
    EnsemblRapid:ENSRNOG00000024509 AllianceGenome:RGD:1565615
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565615
    Summary
    Predicted to enable transcription coactivator activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including defense response to symbiont; positive regulation of NF-kappaB transcription factor activity; and positive regulation of canonical NF-kappaB signal transduction. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm. Orthologous to human TRIM52 (tripartite motif containing 52). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 29.1) See more
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    Genomic context

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    See Trim52 in Genome Data Viewer
    Location:
    15q22
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (89300495..89324140)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (82886237..82924611)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (90364517..90388295)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096902 Neighboring gene sprouty RTK signaling antagonist 2 Neighboring gene protein transport protein Sec61 subunit gamma pseudogene Neighboring gene lactate dehydrogenase A, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Tripartite Motif Containing 52 Positively Regulates NF-κB Signaling by Promoting IκBα Ubiquitination in Lipopolysaccharide-Treated Microglial Cell Activation. Zhang P, et al. Med Sci Monit, 2020 Oct 30. PMID 33122622, Free PMC Article
    2. TRIM52 knockdown inhibits proliferation, inflammatory responses and oxidative stress in IL-1β-induced synovial fibroblasts to alleviate temporomandibular joint osteoarthritis. Ma T, et al. J Cell Mol Med, 2024 Apr. PMID 38520211, Free PMC Article
    3. TRIM52: A nuclear TRIM protein that positively regulates the nuclear factor-kappa B signaling pathway. Fan W, et al. Mol Immunol, 2017 Feb. PMID 28073078
    4. TRIM52 inhibits Japanese Encephalitis Virus replication by degrading the viral NS2A. Fan W, et al. Sci Rep, 2016 Sep 26. PMID 27667714, Free PMC Article
    5. TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity. Uchil PD, et al. J Virol, 2013 Jan. PMID 23077300, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TRIM52 knockdown inhibits proliferation, inflammatory responses and oxidative stress in IL-1beta-induced synovial fibroblasts to alleviate temporomandibular joint osteoarthritis.
      Title: TRIM52 knockdown inhibits proliferation, inflammatory responses and oxidative stress in IL-1β-induced synovial fibroblasts to alleviate temporomandibular joint osteoarthritis.
    2. Tripartite Motif Containing 52 Positively Regulates NF-kappaB Signaling by Promoting IkappaBalpha Ubiquitination in Lipopolysaccharide-Treated Microglial Cell Activation.
      Title: Tripartite Motif Containing 52 Positively Regulates NF-κB Signaling by Promoting IκBα Ubiquitination in Lipopolysaccharide-Treated Microglial Cell Activation.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tripartite motif-containing 52

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106056.1 → NP_001099526.1  tripartite motif-containing 52

      See identical proteins and their annotated locations for NP_001099526.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473951
      UniProtKB/TrEMBL
      A6HUC5, D3ZJ28
      Related
      ENSRNOP00000020876.3, ENSRNOT00000020876.5
      Conserved Domains (1) summary
      cl17238
      Location:20 → 55
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      89300495..89324140
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006252435.5 → XP_006252497.1  tripartite motif-containing 52 isoform X2

      See identical proteins and their annotated locations for XP_006252497.1

      UniProtKB/TrEMBL
      A6HUC5, D3ZJ28
      Conserved Domains (1) summary
      cl17238
      Location:20 → 55
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    2. XM_063274173.1 → XP_063130243.1  tripartite motif-containing 52 isoform X3

    3. XM_063274172.1 → XP_063130242.1  tripartite motif-containing 52 isoform X1

    RNA

    1. XR_010057804.1 RNA Sequence

    2. XR_010057807.1 RNA Sequence

    3. XR_010057808.1 RNA Sequence

    4. XR_010057806.1 RNA Sequence

    5. XR_010057805.1 RNA Sequence

    6. XR_005493708.2 RNA Sequence

    7. XR_005493710.2 RNA Sequence

    8. XR_005493709.2 RNA Sequence

    9. XR_010057809.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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