Agr3 anterior gradient 3, protein disulphide isomerase family member [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Agr3provided by RGD
Official Full Name: anterior gradient 3, protein disulphide isomerase family memberprovided by RGD
Primary source: RGD:1565406
See related: EnsemblRapid:ENSRNOG00000004994 AllianceGenome:RGD:1565406
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1565406
Summary: Predicted to enable dystroglycan binding activity. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in endoplasmic reticulum. Orthologous to human AGR3 (anterior gradient 3, protein disulphide isomerase family member). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 15.7), Uterus (RPKM 2.3) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q16

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (58370701..58393944)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (52643391..52666638)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (55371738..55424233)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables dystroglycan binding	IBA Inferred from Biological aspect of Ancestor more info
enables dystroglycan binding	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: anterior gradient protein 3

Names: anterior gradient 3 homolog; anterior gradient homolog 3; anterior gradient protein 3 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106724.1 → NP_001100194.1 anterior gradient protein 3 precursor

See identical proteins and their annotated locations for NP_001100194.1

Status: PROVISIONAL

Source sequence(s)

CH473947

UniProtKB/TrEMBL

A6HBA3, D3ZIF1

Related

ENSRNOP00000006652.6, ENSRNOT00000006652.8

Conserved Domains (1) summary

cd02960
Location:36 → 165

AGR; Anterior Gradient (AGR) family; members of this family are similar to secreted proteins encoded by the cement gland-specific genes XAG-1 and XAG-2, expressed in the anterior region of dorsal ectoderm of Xenopus. They are implicated in the formation of ...