Dcun1d3 defective in cullin neddylation 1 domain containing 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dcun1d3provided by RGD
Official Full Name: defective in cullin neddylation 1 domain containing 3provided by RGD
Primary source: RGD:1308893
See related: EnsemblRapid:ENSRNOG00000066875 AllianceGenome:RGD:1308893
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: DCNL3; RGD1308893
Summary: Predicted to enable cullin family protein binding activity; ubiquitin conjugating enzyme binding activity; and ubiquitin-like protein binding activity. Predicted to be involved in several processes, including negative regulation of G1/S transition of mitotic cell cycle; protein neddylation; and regulation of protein neddylation. Predicted to be located in several cellular components, including cytosol; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be part of ubiquitin ligase complex. Orthologous to human DCUN1D3 (defective in cullin neddylation 1 domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 68.1), Lung (RPKM 65.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q35

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (183674364..183717002, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (174243001..174285647, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (189626442..189666440, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

UniSTS:235764 (e-PCR)
- UniSTS:235764

24.MMHAP35FRH9.seq (e-PCR)
- UniSTS:123641

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cullin family protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables cullin family protein binding	ISO Inferred from Sequence Orthology more info
enables cullin family protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin conjugating enzyme binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-like protein binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of G1/S transition of mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein neddylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein neddylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein neddylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein neddylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein neddylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell cycle process	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of protein neddylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein neddylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to UV-C	ISO Inferred from Sequence Orthology more info
involved_in response to UV-C	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to gamma radiation	ISO Inferred from Sequence Orthology more info
involved_in response to gamma radiation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: DCN1-like protein 3

Names: DCN1, defective in cullin neddylation 1, domain containing 3; DCUN1 domain-containing protein 3; defective in cullin neddylation protein 1-like protein 3

NP_001020057.1

EC 3.1.-.-

XP_008757972.1

EC 3.1.-.-

XP_038934549.1

EC 3.1.-.-

XP_038934556.1

EC 3.1.-.-

XP_063119704.1

EC 3.1.-.-

XP_063119709.1

EC 3.1.-.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024886.1 → NP_001020057.1 DCN1-like protein 3

See identical proteins and their annotated locations for NP_001020057.1

Status: PROVISIONAL

Source sequence(s)

BC097462

UniProtKB/Swiss-Prot

Q4V8B2

UniProtKB/TrEMBL

A0A8L2Q9V9, A6I8P0

Related

ENSRNOP00000019167.6, ENSRNOT00000019167.6

Conserved Domains (1) summary

pfam03556
Location:164 → 276

Cullin_binding; Cullin binding

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

183674364..183717002 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039078621.2 → XP_038934549.1 DCN1-like protein 3 isoform X1

UniProtKB/Swiss-Prot

Q4V8B2

UniProtKB/TrEMBL

A0A8L2Q9V9, A6I8P0

Conserved Domains (1) summary

pfam03556
Location:164 → 276

Cullin_binding; Cullin binding
XM_008759750.4 → XP_008757972.1 DCN1-like protein 3 isoform X1

See identical proteins and their annotated locations for XP_008757972.1

UniProtKB/Swiss-Prot

Q4V8B2

UniProtKB/TrEMBL

A0A8L2Q9V9, A6I8P0

Conserved Domains (1) summary

pfam03556
Location:164 → 276

Cullin_binding; Cullin binding
XM_063263634.1 → XP_063119704.1 DCN1-like protein 3 isoform X1

UniProtKB/Swiss-Prot

Q4V8B2

UniProtKB/TrEMBL

A0A8L2Q9V9, A6I8P0
XM_063263639.1 → XP_063119709.1 DCN1-like protein 3 isoform X1

UniProtKB/Swiss-Prot

Q4V8B2

UniProtKB/TrEMBL

A0A8L2Q9V9, A6I8P0
XM_039078628.2 → XP_038934556.1 DCN1-like protein 3 isoform X1

UniProtKB/Swiss-Prot

Q4V8B2

UniProtKB/TrEMBL

A0A8L2Q9V9, A6I8P0

Conserved Domains (1) summary

pfam03556
Location:164 → 276

Cullin_binding; Cullin binding