Aim2 absent in melanoma 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Aim2provided by RGD
Official Full Name: absent in melanoma 2provided by RGD
Primary source: RGD:1307283
See related: EnsemblRapid:ENSRNOG00000003480 AllianceGenome:RGD:1307283
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including cysteine-type endopeptidase activator activity; identical protein binding activity; and signaling adaptor activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; protein-containing complex assembly; and regulation of DNA-binding transcription factor activity. Predicted to act upstream of or within cellular response to xenobiotic stimulus and positive regulation of interleukin-1 beta production. Predicted to be located in mitochondrion. Predicted to be part of AIM2 inflammasome complex. Predicted to be active in cytosol; nucleoplasm; and site of double-strand break. Orthologous to human AIM2 (absent in melanoma 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 49.0), Thymus (RPKM 43.4) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q24

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (88397516..88439325)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (85865206..85906996)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (91919834..91963080)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role of AIM2 Gene Knockdown Mechanism in Diabetic Cardiomyopathy: an In Vivo and Ex Vivo Study.
Title: Role of AIM2 Gene Knockdown Mechanism in Diabetic Cardiomyopathy: an In Vivo and Ex Vivo Study.
AIM2-driven inflammasome activation in heart failure.
Title: AIM2-driven inflammasome activation in heart failure.
Gonadal Hormones E2 and P Mitigate Cerebral Ischemia-Induced Upregulation of the AIM2 and NLRC4 Inflammasomes in Rats.
Title: Gonadal Hormones E2 and P Mitigate Cerebral Ischemia-Induced Upregulation of the AIM2 and NLRC4 Inflammasomes in Rats.
Long non-coding RNA MEG3 promotes cerebral ischemia-reperfusion injury through increasing pyroptosis by targeting miR-485/AIM2 axis.
Title: Long non-coding RNA MEG3 promotes cerebral ischemia-reperfusion injury through increasing pyroptosis by targeting miR-485/AIM2 axis.
The importance of HIN-200 proteins in disease now is beginning to be understood as they appear to be involved in autoimmunity and may act as tumor suppressor proteins.
Title: The HIN-200 family: more than interferon-inducible genes?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase activator activity	ISO Inferred from Sequence Orthology more info
enables double-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables pattern recognition receptor activity	ISO Inferred from Sequence Orthology more info
enables signaling adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in AIM2 inflammasome complex assembly	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in T cell homeostasis	ISO Inferred from Sequence Orthology more info
involved_in activation of innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in activation of innate immune response	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in brain development	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interferon-beta	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to interferon-beta	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in neuron cellular homeostasis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of defense response to virus by host	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in pyroptosome complex assembly	ISO Inferred from Sequence Orthology more info
involved_in pyroptotic inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in regulation of behavior	ISO Inferred from Sequence Orthology more info
involved_in tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of AIM2 inflammasome complex	IBA Inferred from Biological aspect of Ancestor more info
part_of AIM2 inflammasome complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in site of double-strand break	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interferon-inducible protein AIM2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427493.1 → NP_001414422.1 interferon-inducible protein AIM2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

D4A9W0

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

88397516..88439325

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039091426.2 → XP_038947354.1 interferon-inducible protein AIM2 isoform X1

UniProtKB/TrEMBL

D4A9W0

Conserved Domains (2) summary

cd08305
Location:10 → 77

Pyrin; a protein-protein interaction domain

pfam02760
Location:156 → 323

HIN; HIN-200/IF120x domain
XM_222949.10 → XP_222949.5 interferon-inducible protein AIM2 isoform X1

See identical proteins and their annotated locations for XP_222949.5

UniProtKB/TrEMBL

D4A9W0

Conserved Domains (2) summary

cd08305
Location:10 → 77

Pyrin; a protein-protein interaction domain

pfam02760
Location:156 → 323

HIN; HIN-200/IF120x domain
XM_063272376.1 → XP_063128446.1 interferon-inducible protein AIM2 isoform X1

UniProtKB/TrEMBL

D4A9W0
XM_006250336.5 → XP_006250398.1 interferon-inducible protein AIM2 isoform X1

See identical proteins and their annotated locations for XP_006250398.1

UniProtKB/TrEMBL

D4A9W0

Related

ENSRNOP00000033110.5, ENSRNOT00000037655.9

Conserved Domains (2) summary

cd08305
Location:10 → 77

Pyrin; a protein-protein interaction domain

pfam02760
Location:156 → 323

HIN; HIN-200/IF120x domain
XM_008769802.4 → XP_008768024.1 interferon-inducible protein AIM2 isoform X1

See identical proteins and their annotated locations for XP_008768024.1

UniProtKB/TrEMBL

D4A9W0

Conserved Domains (2) summary

cd08305
Location:10 → 77

Pyrin; a protein-protein interaction domain

pfam02760
Location:156 → 323

HIN; HIN-200/IF120x domain
XM_039091427.2 → XP_038947355.1 interferon-inducible protein AIM2 isoform X2

Conserved Domains (1) summary

pfam02760
Location:66 → 233

HIN; HIN-200/IF120x domain