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    Spred2 sprouty-related, EVH1 domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305539, updated on 9-Dec-2024

    Summary

    Official Symbol
    Spred2provided by RGD
    Official Full Name
    sprouty-related, EVH1 domain containing 2provided by RGD
    Primary source
    RGD:1309304
    See related
    EnsemblRapid:ENSRNOG00000004888 AllianceGenome:RGD:1309304
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein kinase binding activity; protein serine/threonine kinase inhibitor activity; and stem cell factor receptor binding activity. Predicted to be involved in negative regulation of cell differentiation; regulation of protein modification process; and regulation of signal transduction. Predicted to act upstream of or within negative regulation of MAPK cascade. Predicted to be located in cytoplasmic vesicle. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Noonan syndrome. Orthologous to human SPRED2 (sprouty related EVH1 domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 58.9), Brain (RPKM 57.3) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Spred2 in Genome Data Viewer
    Location:
    14q22
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (98350577..98452143)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (94149210..94250787)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (104268362..104290206)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096680 Neighboring gene uncharacterized LOC120096681 Neighboring gene transfer RNA proline (anticodon AGG) 79 Neighboring gene actin related protein 1A, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein kinase binding  
    enables protein kinase binding  
    enables protein kinase binding  
    enables protein serine/threonine kinase inhibitor activity  
    enables stem cell factor receptor binding  
    Process Evidence Code Pubs
    involved_in negative regulation of ERK1 and ERK2 cascade  
    involved_in negative regulation of ERK1 and ERK2 cascade  
    involved_in negative regulation of ERK1 and ERK2 cascade  
    acts_upstream_of_or_within negative regulation of MAPK cascade  
    involved_in negative regulation of epithelial to mesenchymal transition  
    involved_in negative regulation of epithelial to mesenchymal transition  
    involved_in negative regulation of lens fiber cell differentiation  
    involved_in negative regulation of lens fiber cell differentiation  
    involved_in negative regulation of peptidyl-threonine phosphorylation  
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway  
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway  
    involved_in positive regulation of DNA damage response, signal transduction by p53 class mediator  
    involved_in regulation of protein deacetylation  
    involved_in regulation of signal transduction  
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in transport vesicle membrane  

    General protein information

    Preferred Names
    sprouty-related, EVH1 domain-containing protein 2
    Names
    spred-2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001047094.3NP_001040559.1  sprouty-related, EVH1 domain-containing protein 2

      See identical proteins and their annotated locations for NP_001040559.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/Swiss-Prot
      Q3C2P8
      UniProtKB/TrEMBL
      A0A0G2K1D0, A6JQ11
      Related
      ENSRNOP00000071793.2, ENSRNOT00000079874.3
      Conserved Domains (2) summary
      cd10574
      Location:12124
      EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
      pfam05210
      Location:298403
      Sprouty; Sprouty protein (Spry)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      98350577..98452143
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063273235.1XP_063129305.1  sprouty-related, EVH1 domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K1D0, A0A8L2UHU3
      Related
      ENSRNOP00000102473.1, ENSRNOT00000161751.1
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