Cxcl17 C-X-C motif chemokine ligand 17 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cxcl17provided by RGD
Official Full Name: C-X-C motif chemokine ligand 17provided by RGD
Primary source: RGD:1304717
See related: EnsemblRapid:ENSRNOG00000037814 AllianceGenome:RGD:1304717
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1304717
Summary: Predicted to be involved in several processes, including macrophage chemotaxis; positive regulation of ERK1 and ERK2 cascade; and positive regulation of leukocyte chemotaxis. Predicted to be active in extracellular space. Orthologous to human CXCL17 (C-X-C motif chemokine ligand 17). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 328.5), Uterus (RPKM 36.4) and 2 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 1q21

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (90112561..90124648, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (80984751..80996842, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (82267381..82279145, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CXCL17 in the gastric lamina propria may play an important role in tissue repair and anti-inflammation, both of which help to maintain the integrity of the gastric mucosa.
Title: CXCL17, an orphan chemokine, acts as a novel angiogenic and anti-inflammatory factor.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in macrophage chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in macrophage chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of macrophage chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of macrophage chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of monocyte chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of monocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of monocyte chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of vascular endothelial growth factor production	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of vascular endothelial growth factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular endothelial growth factor production	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info

General protein information

Go to the top of the page Help

Preferred Names: C-X-C motif chemokine 17

Names: VEGF co-regulated chemokine 1; VEGF coregulated chemokine 1; chemokine (C-X-C motif) ligand 17

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107491.1 → NP_001100961.1 C-X-C motif chemokine 17 precursor

See identical proteins and their annotated locations for NP_001100961.1

Status: PROVISIONAL

Source sequence(s)

CH473979

UniProtKB/TrEMBL

A6J960, D4A875

Related

ENSRNOP00000054242.2, ENSRNOT00000057433.4

Conserved Domains (1) summary

pfam15211
Location:23 → 111

CXCL17; VEGF co-regulated chemokine 1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

90112561..90124648 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039111464.2 → XP_038967392.1 C-X-C motif chemokine 17 isoform X1

Conserved Domains (1) summary

pfam15211
Location:26 → 84

CXCL17; VEGF co-regulated chemokine 1