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    Slco6c1 solute carrier organic anion transporter family, member 6c1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287006, updated on 9-Dec-2024

    Summary

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    Symbol
    Slco6c1provided by RGD
    Full Name
    solute carrier organic anion transporter family, member 6c1provided by RGD
    Primary source
    RGD:708431
    See related
    EnsemblRapid:ENSRNOG00000013792 AllianceGenome:RGD:708431
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    GST-2
    Summary
    Enables organic anion transmembrane transporter activity. Involved in organic anion transport. Predicted to be part of CatSper complex. Predicted to be active in basolateral plasma membrane. Orthologous to human SLCO6A1 (solute carrier organic anion transporter family member 6A1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 122.7) See more
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    Genomic context

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    See Slco6c1 in Genome Data Viewer
    Location:
    9q36
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (104947509..105028079, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (97500028..97580776, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (104622119..104700657, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 40 Neighboring gene solute carrier organic anion transporter family member 6c1 like, pseudogene 1 Neighboring gene uncharacterized LOC134480421 Neighboring gene solute carrier organic anion transporter family, member 6d1 Neighboring gene tumor protein, translationally-controlled 1 pseudogene 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Interactions of cationic drugs and cardiac glycosides at the hepatic uptake level: studies in the rat in vivo, isolated perfused rat liver, isolated rat hepatocytes and oocytes expressing oatp2. Meijer DK, et al. Arch Pharm Res, 2002 Aug. PMID 12214846
    2. Identification and characterization of novel rat and human gonad-specific organic anion transporters. Suzuki T, et al. Mol Endocrinol, 2003 Jul. PMID 12677006
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. a novel organic anion transporter expressed at high levels in the testis
      Title: Identification and characterization of novel rat and human gonad-specific organic anion transporters.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables organic anion transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables sodium-independent organic anion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in organic anion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sodium-independent organic anion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of CatSper complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier organic anion transporter family, member 6c1
    Names
    gonad-specific transporter 2
    solute carrier organic anion transporter family member 6A1-like
    testis-specific transporter TST-2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173338.1 → NP_775460.1  solute carrier organic anion transporter family, member 6c1

      See identical proteins and their annotated locations for NP_775460.1

      Status: PROVISIONAL

      Source sequence(s)
      AF326113
      UniProtKB/TrEMBL
      A6JR55, G3V7R7, Q8K4K9
      Related
      ENSRNOP00000068805.1, ENSRNOT00000077480.3
      Conserved Domains (3) summary
      cd06174
      Location:90 → 457
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      cd01330
      Location:481 → 534
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      pfam03137
      Location:88 → 648
      OATP; Organic Anion Transporter Polypeptide (OATP) family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      104947509..105028079 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266805.1 → XP_063122875.1  solute carrier organic anion transporter family, member 6c1 isoform X7

    2. XM_063266804.1 → XP_063122874.1  solute carrier organic anion transporter family, member 6c1 isoform X5

    3. XM_063266808.1 → XP_063122878.1  solute carrier organic anion transporter family, member 6c1 isoform X12

    4. XM_039083104.2 → XP_038939032.1  solute carrier organic anion transporter family, member 6c1 isoform X6

      Conserved Domains (1) summary
      cl28910
      Location:101 → 437
      MFS; Major Facilitator Superfamily

    5. XM_063266802.1 → XP_063122872.1  solute carrier organic anion transporter family, member 6c1 isoform X3

      UniProtKB/TrEMBL
      A6JR55, G3V7R7

    6. XM_063266800.1 → XP_063122870.1  solute carrier organic anion transporter family, member 6c1 isoform X1

      UniProtKB/TrEMBL
      A6JR55, G3V7R7

    7. XM_039083103.2 → XP_038939031.1  solute carrier organic anion transporter family, member 6c1 isoform X2

      UniProtKB/TrEMBL
      A6JR55, G3V7R7
      Conserved Domains (1) summary
      cl28910
      Location:86 → 503
      MFS; Major Facilitator Superfamily

    8. XM_063266806.1 → XP_063122876.1  solute carrier organic anion transporter family, member 6c1 isoform X8

    9. XM_063266803.1 → XP_063122873.1  solute carrier organic anion transporter family, member 6c1 isoform X4

    10. XM_039083106.2 → XP_038939034.1  solute carrier organic anion transporter family, member 6c1 isoform X10

      Conserved Domains (1) summary
      cl28910
      Location:86 → 408
      MFS; Major Facilitator Superfamily

    11. XM_039083105.2 → XP_038939033.2  solute carrier organic anion transporter family, member 6c1 isoform X9

    12. XM_063266807.1 → XP_063122877.1  solute carrier organic anion transporter family, member 6c1 isoform X11

    RNA

    1. XR_005488857.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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