U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Srsf12 serine and arginine rich splicing factor 12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297962, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Srsf12provided by RGD
    Official Full Name
    serine and arginine rich splicing factor 12provided by RGD
    Primary source
    RGD:1561162
    See related
    EnsemblRapid:ENSRNOG00000069984 AllianceGenome:RGD:1561162
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Srrp; Srrp35; RGD1561162
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in mRNA 5'-splice site recognition and regulation of alternative mRNA splicing, via spliceosome. Predicted to be active in nuclear speck. Orthologous to human SRSF12 (serine and arginine rich splicing factor 12). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 58.4), Testes (RPKM 47.2) and 7 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Srsf12 in Genome Data Viewer
    Location:
    5q21
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (52402033..52427839)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (47606526..47631509)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (48456777..48484017)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene gamma-aminobutyric acid type A receptor subunit rho 1 Neighboring gene U6 spliceosomal RNA Neighboring gene peptidase M20 domain containing 2 Neighboring gene proline-rich nuclear receptor coactivator 1 Neighboring gene uncharacterized LOC108350948

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Serine-arginine (SR) protein-like factors that antagonize authentic SR proteins and regulate alternative splicing. Cowper AE, et al. J Biol Chem, 2001 Dec 28. PMID 11684676
    2. Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors. Chen YI, et al. Nucleic Acids Res, 2007. PMID 17537823, Free PMC Article
    3. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mRNA 5'-splice site recognition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    serine/arginine-rich splicing factor 12
    Names
    35 kDa SR repressor protein
    35 kDa serine-arginine repressor
    serine-arginine repressor protein (35 kDa)
    serine-arginine repressor protein 35

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135711.2 → NP_001129183.1  serine/arginine-rich splicing factor 12

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      Conserved Domains (1) summary
      cd12559
      Location:6 → 99
      RRM_SRSF10; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor 10 (SRSF10) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      52402033..52427839
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109432.2 → XP_038965360.2  serine/arginine-rich splicing factor 12 isoform X1

      Related
      ENSRNOP00000088462.1, ENSRNOT00000116727.2

    2. XM_039109433.2 → XP_038965361.1  serine/arginine-rich splicing factor 12 isoform X2

      Conserved Domains (1) summary
      cd12312
      Location:2 → 72
      RRM_SRSF10_SRSF12; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor SRSF10, SRSF12 and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.