H4c14 H4 clustered histone 14 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: H4c14provided by RGD
Official Full Name: H4 clustered histone 14provided by RGD
Primary source: RGD:1307448
See related: AllianceGenome:RGD:1307448
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: H4c2; H4c16; H4f16; Hist2h4; Hist4h4
Summary: Predicted to be a structural constituent of chromatin. Predicted to be involved in negative regulation of megakaryocyte differentiation and nucleosome assembly. Predicted to be located in nucleus. Predicted to be part of CENP-A containing nucleosome. Orthologous to several human genes including H4C2 (H4 clustered histone 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Location:: 2q34

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (186520468..186520863, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (183831601..183831996, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (198411955..198412350, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH142719 (e-PCR)
- UniSTS:231966

RH132342 (e-PCR)
- UniSTS:215625

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables structural constituent of chromatin	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of megakaryocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in nucleosome assembly	ISO Inferred from Sequence Orthology more info
involved_in ossification	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of CENP-A containing nucleosome	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	TAS Traceable Author Statement more info
part_of nucleosome	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: histone H4

Names: histone 2, H4; histone cluster 2, H4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.