U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Sytl5 synaptotagmin-like 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 302538, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Sytl5provided by RGD
    Official Full Name
    synaptotagmin-like 5provided by RGD
    Primary source
    RGD:631342
    See related
    EnsemblRapid:ENSRNOG00000003585 AllianceGenome:RGD:631342
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable neurexin family protein binding activity. Predicted to be involved in exocytosis. Predicted to be located in membrane. Predicted to be active in exocytic vesicle and plasma membrane. Orthologous to human SYTL5 (synaptotagmin like 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 22.2), Testes (RPKM 14.2) and 4 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Sytl5 in Genome Data Viewer
    Location:
    Xq12
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (15461215..15702660, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (12775529..13030134, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (13857669..14109592)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene transfer RNA alanine (anticodon CGC) 4 Neighboring gene sushi-repeat-containing protein, X-linked Neighboring gene H2A.L variant histone 3 Neighboring gene H2A.P histone Neighboring gene small nucleolar RNA SNORA62/SNORA6 family Neighboring gene uncharacterized LOC102551428 Neighboring gene uncharacterized LOC120099204

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Synaptotagmin-like protein 5: a novel Rab27A effector with C-terminal tandem C2 domains. Kuroda TS, et al. Biochem Biophys Res Commun, 2002 May 10. PMID 12051743
    2. Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells. Fukuda M. J Biol Chem, 2003 Apr 25. PMID 12590134
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables neurexin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in exocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    synaptotagmin-like protein 5
    Names
    synaptotagmin 15

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001434004.1 → NP_001420933.1  synaptotagmin-like protein 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/Swiss-Prot
      Q812E4
      UniProtKB/TrEMBL
      G3V6F7

    2. NM_178333.2 → NP_848016.2  synaptotagmin-like protein 5 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/Swiss-Prot
      Q812E4
      UniProtKB/TrEMBL
      A0A8I6AHG7, A6K022
      Related
      ENSRNOP00000094316.2, ENSRNOT00000114439.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      15461215..15702660 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279916.1 → XP_063135986.1  synaptotagmin-like protein 5 isoform X3

      Related
      ENSRNOP00000004785.5, ENSRNOT00000004785.7

    2. XM_063279914.1 → XP_063135984.1  synaptotagmin-like protein 5 isoform X1

    3. XM_039099627.2 → XP_038955555.1  synaptotagmin-like protein 5 isoform X1

      UniProtKB/Swiss-Prot
      Q812E4
      UniProtKB/TrEMBL
      A0A8I6AHG7, A6K022
      Conserved Domains (4) summary
      cd04020
      Location:567 → 745
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:430 → 553
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15766
      Location:62 → 108
      FYVE_Slp5; FYVE-related domain found in synaptotagmin-like protein 5 (Slp5) and similar proteins
      cl22851
      Location:11 → 123
      PHD_SF; PHD finger superfamily

    4. XM_063279915.1 → XP_063135985.1  synaptotagmin-like protein 5 isoform X3

      UniProtKB/Swiss-Prot
      Q812E4
      UniProtKB/TrEMBL
      G3V6F7

    5. XM_039099626.2 → XP_038955554.1  synaptotagmin-like protein 5 isoform X1

      UniProtKB/Swiss-Prot
      Q812E4
      UniProtKB/TrEMBL
      A0A8I6AHG7, A6K022
      Conserved Domains (4) summary
      cd04020
      Location:567 → 745
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:430 → 553
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15766
      Location:62 → 108
      FYVE_Slp5; FYVE-related domain found in synaptotagmin-like protein 5 (Slp5) and similar proteins
      cl22851
      Location:11 → 123
      PHD_SF; PHD finger superfamily

    6. XM_008773070.4 → XP_008771292.1  synaptotagmin-like protein 5 isoform X2

      UniProtKB/Swiss-Prot
      Q812E4
      Conserved Domains (3) summary
      cd04020
      Location:564 → 742
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:427 → 550
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15766
      Location:62 → 108
      FYVE_Slp5; FYVE-related domain found in synaptotagmin-like protein 5 (Slp5) and similar proteins

    7. XM_017601991.3 → XP_017457480.1  synaptotagmin-like protein 5 isoform X1

      UniProtKB/Swiss-Prot
      Q812E4
      UniProtKB/TrEMBL
      A0A8I6AHG7, A6K022
      Conserved Domains (4) summary
      cd04020
      Location:567 → 745
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:430 → 553
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15766
      Location:62 → 108
      FYVE_Slp5; FYVE-related domain found in synaptotagmin-like protein 5 (Slp5) and similar proteins
      cl22851
      Location:11 → 123
      PHD_SF; PHD finger superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q812E4.1 GenPept UniProtKB/Swiss-Prot:Q812E4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools