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    Ropn1 rhophilin associated tail protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288053, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ropn1provided by RGD
    Official Full Name
    rhophilin associated tail protein 1provided by RGD
    Primary source
    RGD:1310675
    See related
    EnsemblRapid:ENSRNOG00000002187 AllianceGenome:RGD:1310675
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in several processes, including flagellated sperm motility; protein localization to cilium; and sperm capacitation. Predicted to be located in sperm cytoplasmic droplet and sperm principal piece. Predicted to be active in cytoplasm and motile cilium. Orthologous to several human genes including ROPN1 (rhophilin associated tail protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 780.7) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ropn1 in Genome Data Viewer
    Location:
    11q22
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (79603053..79632344, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (66097854..66127148, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (69326785..69355788, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene non-histone chromosomal protein HMG-17-like Neighboring gene uncharacterized LOC120095665 Neighboring gene coiled-coil domain containing 14 Neighboring gene kalirin, RhoGEF kinase Neighboring gene G2/mitotic-specific cyclin-B1-like Neighboring gene uncharacterized LOC120095553

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Loss of R2D2 proteins ROPN1 and ROPN1L causes defects in murine sperm motility, phosphorylation, and fibrous sheath integrity. Fiedler SE, et al. Biol Reprod, 2013 Feb. PMID 23303679, Free PMC Article
    2. Loss of ASP but not ROPN1 reduces mammalian ciliary motility. Fiedler SE, et al. Cytoskeleton (Hoboken), 2012 Jan. PMID 22021175, Free PMC Article
    3. Protein kinase A RII-like (R2D2) proteins exhibit differential localization and AKAP interaction. Newell AE, et al. Cell Motil Cytoskeleton, 2008 Jul. PMID 18421703
    4. Identification of sperm-specific proteins that interact with A-kinase anchoring proteins in a manner similar to the type II regulatory subunit of PKA. Carr DW, et al. J Biol Chem, 2001 May 18. PMID 11278869
    5. Pooled-matrix protein interaction screens using Barcode Fusion Genetics. Yachie N, et al. Mol Syst Biol, 2016 Apr 22. PMID 27107012, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC116277

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cilium organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in flagellated sperm motility ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within protein localization to cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in sperm capacitation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within sperm capacitation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sperm capacitation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in motile cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm cytoplasmic droplet ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm principal piece ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ropporin-1
    Names
    rhophilin-associated protein 1
    ropporin, rhophilin associated protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025628.1 → NP_001020799.1  ropporin-1

      See identical proteins and their annotated locations for NP_001020799.1

      Status: PROVISIONAL

      Source sequence(s)
      BC099132
      UniProtKB/Swiss-Prot
      Q4KLL5
      UniProtKB/TrEMBL
      A6IRI7
      Related
      ENSRNOP00000002975.3, ENSRNOT00000002975.7
      Conserved Domains (1) summary
      cl02594
      Location:10 → 41
      DD_R_PKA; Dimerization/Docking domain of the Regulatory subunit of cAMP-dependent protein kinase and similar domains

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      79603053..79632344 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006248431.5 → XP_006248493.1  ropporin-1 isoform X1

      See identical proteins and their annotated locations for XP_006248493.1

      UniProtKB/Swiss-Prot
      Q4KLL5
      UniProtKB/TrEMBL
      A6IRI7
      Conserved Domains (1) summary
      cl02594
      Location:10 → 41
      DD_R_PKA; Dimerization/Docking domain of the Regulatory subunit of cAMP-dependent protein kinase and similar domains
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4KLL5.1 GenPept UniProtKB/Swiss-Prot:Q4KLL5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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