Irak2 interleukin-1 receptor-associated kinase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Irak2provided by RGD
Official Full Name: interleukin-1 receptor-associated kinase 2provided by RGD
Primary source: RGD:1309584
See related: EnsemblRapid:ENSRNOG00000021817 AllianceGenome:RGD:1309584
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable protein heterodimerization activity; protein homodimerization activity; and signaling adaptor activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; negative regulation of NF-kappaB transcription factor activity; and regulation of signal transduction. Predicted to act upstream of or within negative regulation of DNA-binding transcription factor activity and positive regulation of NF-kappaB transcription factor activity. Predicted to be located in cytosol. Predicted to be active in cytoplasm; nucleus; and plasma membrane. Orthologous to human IRAK2 (interleukin 1 receptor associated kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 127.7), Lung (RPKM 80.6) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q42

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (148341704..148398211)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (146786004..146842615)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (145594575..145651066)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Elevated circulating IL-1beta contributed to promote ER stress- induced myocytes apoptosis by affecting IRAK-2/CHOP pathway in diabetic cardiomyopathy.
Title: Circulating interleukin-1β promotes endoplasmic reticulum stress-induced myocytes apoptosis in diabetic cardiomyopathy via interleukin-1 receptor-associated kinase-2.
TRAF6 and interleukin receptor-associated kinase 2 are novel binding partners for PS1, and IL-1R1 is a new substrate for presenilin-dependent gamma-secretase cleavage
Title: Interleukin-1 receptor type 1 is a substrate for gamma-secretase-dependent regulated intramembrane proteolysis.
Expression of Irak2 increases ~ 15-fold at night in the rat pineal gland, as a result of adrenergic-cyclic AMP signalling. Night time levels are >15-fold greater than median expression levels in other tissues.
Title: Night/day changes in pineal expression of >600 genes: central role of adrenergic/cAMP signaling.

Submit: New GeneRIF Correction

General gene information

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Markers

RH134608 (e-PCR)
- UniSTS:217888

D4Rat60 (e-PCR), detects polymorphism
- UniSTS:118855

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables signaling adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Toll signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in biological_process	ND No biological Data available more info
involved_in canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in interleukin-1-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in interleukin-1-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipopolysaccharide-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipopolysaccharide-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
NOT acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
NOT acts_upstream_of_or_within protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in response to interleukin-1	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in toll-like receptor 4 signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: interleukin-1 receptor-associated kinase-like 2

Names: IRAK-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025422.1 → NP_001020593.1 interleukin-1 receptor-associated kinase-like 2

See identical proteins and their annotated locations for NP_001020593.1

Status: PROVISIONAL

Source sequence(s)

BC098060

UniProtKB/Swiss-Prot

Q4QQS0

UniProtKB/TrEMBL

A0A8I5ZWK6, A6IBT6

Related

ENSRNOP00000034508.4, ENSRNOT00000029819.6

Conserved Domains (2) summary

cd08795
Location:3 → 91

Death_IRAK2; Death domain of Interleukin 1 Receptor Associated Kinase-2

cl21453
Location:216 → 504

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

148341704..148398211

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039107858.2 → XP_038963786.1 interleukin-1 receptor-associated kinase-like 2 isoform X1

UniProtKB/TrEMBL

A0A8I5ZWK6, A0A8I6ATU6

Related

ENSRNOP00000097081.1, ENSRNOT00000112620.2

Conserved Domains (2) summary

cd08795
Location:3 → 91

Death_IRAK2; Death domain of Interleukin 1 Receptor Associated Kinase-2

cl21453
Location:168 → 456

PKc_like; Protein Kinases, catalytic domain
XM_063286304.1 → XP_063142374.1 interleukin-1 receptor-associated kinase-like 2 isoform X2

UniProtKB/TrEMBL

A0A8I5ZWK6

Related

ENSRNOP00000082209.1, ENSRNOT00000096002.2