Bhlhe23 basic helix-loop-helix family, member e23 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bhlhe23provided by RGD
Official Full Name: basic helix-loop-helix family, member e23provided by RGD
Primary source: RGD:1559760
See related: EnsemblRapid:ENSRNOG00000010312 AllianceGenome:RGD:1559760
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Bhlhb4; RGD1559760
Summary: Predicted to enable DNA-binding transcription factor activity and E-box binding activity. Predicted to be involved in neuron differentiation; positive regulation of transcription by RNA polymerase II; and sensory organ development. Predicted to act upstream of or within negative regulation of retinal cell programmed cell death; post-embryonic eye morphogenesis; and retinal rod cell development. Predicted to be active in nucleus. Orthologous to human BHLHE23 (basic helix-loop-helix family member e23). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: 3q43

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (188266572..188268786, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (167889009..167891223, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (176279997..176282211, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables E-box binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in axon development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of retinal cell programmed cell death	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within post-embryonic eye morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of retinal cell programmed cell death	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retinal rod cell development	ISO Inferred from Sequence Orthology more info
involved_in sensory organ development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: class E basic helix-loop-helix protein 23

Names: basic helix-loop-helix domain containing, class B4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109211.1 → NP_001102681.1 class E basic helix-loop-helix protein 23

See identical proteins and their annotated locations for NP_001102681.1

Status: PROVISIONAL

Source sequence(s)

CH474066

UniProtKB/TrEMBL

A6KM77, D3ZU26

Related

ENSRNOP00000013690.2, ENSRNOT00000013690.5

Conserved Domains (1) summary

cd18954
Location:99 → 168

bHLH_TS_bHLHe22_bHLHb5; basic helix-loop-helix (bHLH) domain found in Class E basic helix-loop-helix protein 22 (bHLHe22) and similar proteins