Catsper3 cation channel, sperm associated 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Catsper3provided by RGD
Official Full Name: cation channel, sperm associated 3provided by RGD
Primary source: RGD:1305700
See related: EnsemblRapid:ENSRNOG00000011374 AllianceGenome:RGD:1305700
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable voltage-gated calcium channel activity. Predicted to be involved in flagellated sperm motility; sodium ion transport; and sperm capacitation. Predicted to act upstream of or within establishment of localization in cell. Predicted to be located in endoplasmic reticulum. Predicted to be part of CatSper complex. Predicted to be active in acrosomal vesicle. Orthologous to human CATSPER3 (cation channel sperm associated 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 62.4) and Brain (RPKM 1.2) See more
Orthologs: human mouse all
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Genomic context

Location:: 17p14

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (8820738..8846063, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (8810122..8840881, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (8900034..8925385, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables voltage-gated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated calcium channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
involved_in flagellated sperm motility	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within flagellated sperm motility	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sodium ion transport	ISO Inferred from Sequence Orthology more info
involved_in sperm capacitation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sperm capacitation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of CatSper complex	IBA Inferred from Biological aspect of Ancestor more info
part_of CatSper complex	ISO Inferred from Sequence Orthology more info
is_active_in acrosomal vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in acrosomal vesicle	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cation channel sperm-associated protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106101.2 → NP_001099571.2 cation channel sperm-associated protein 3 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000017
NM_001414392.1 → NP_001401321.1 cation channel sperm-associated protein 3 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000017

UniProtKB/TrEMBL

F1LZS9

Related

ENSRNOP00000015163.7, ENSRNOT00000015163.9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

8820738..8846063 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039095469.2 → XP_038951397.1 cation channel sperm-associated protein 3 isoform X4

Conserved Domains (1) summary

cl00456
Location:54 → 128

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
XM_039095467.2 → XP_038951395.1 cation channel sperm-associated protein 3 isoform X2

UniProtKB/TrEMBL

A0A8I6G2E9

Conserved Domains (1) summary

pfam00520
Location:77 → 189

Ion_trans; Ion transport protein
XM_063276143.1 → XP_063132213.1 cation channel sperm-associated protein 3 isoform X1
XM_039095468.2 → XP_038951396.1 cation channel sperm-associated protein 3 isoform X3

Conserved Domains (1) summary

pfam00520
Location:9 → 170

Ion_trans; Ion transport protein