Clec12b C-type lectin domain family 12, member B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Clec12bprovided by RGD
Official Full Name: C-type lectin domain family 12, member Bprovided by RGD
Primary source: RGD:1560487
See related: EnsemblRapid:ENSRNOG00000053638 AllianceGenome:RGD:1560487
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1560487
Summary: Predicted to enable protein phosphatase binding activity and signaling receptor inhibitor activity. Predicted to be involved in several processes, including melanocyte proliferation; natural killer cell inhibitory signaling pathway; and regulation of signal transduction. Predicted to be part of protein-containing complex. Predicted to be active in external side of plasma membrane. Orthologous to human CLEC12B (C-type lectin domain family 12 member B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 48.9), Lung (RPKM 9.5) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q42

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (164512893..164529846, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (162827462..162843821, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (163140883..163157996, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables protein phosphatase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in melanocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in natural killer cell inhibitory signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in natural killer cell inhibitory signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of receptor signaling pathway via STAT	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of signaling receptor activity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: C-type lectin domain family 12 member B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109353.1 → NP_001102823.1 C-type lectin domain family 12 member B

See identical proteins and their annotated locations for NP_001102823.1

Status: PROVISIONAL

Source sequence(s)

CH473964

UniProtKB/TrEMBL

A6IM42, D4ABQ8

Related

ENSRNOP00000074348.1, ENSRNOT00000089712.3

Conserved Domains (1) summary

cd03593
Location:142 → 264

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

164512893..164529846 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006237092.5 → XP_006237154.1 C-type lectin domain family 12 member B isoform X1

See identical proteins and their annotated locations for XP_006237154.1

UniProtKB/TrEMBL

A6IM42, D4ABQ8

Conserved Domains (1) summary

cd03593
Location:142 → 264

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
XM_063286617.1 → XP_063142687.1 C-type lectin domain family 12 member B isoform X2