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    Cby1 chibby 1, beta catenin antagonist [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246768, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cby1provided by RGD
    Official Full Name
    chibby 1, beta catenin antagonistprovided by RGD
    Primary source
    RGD:708481
    See related
    EnsemblRapid:ENSRNOG00000090732 AllianceGenome:RGD:708481
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pgea1
    Summary
    Predicted to enable beta-catenin binding activity and protein homodimerization activity. Predicted to be involved in several processes, including fat cell differentiation; negative regulation of Wnt signaling pathway; and protein homotetramerization. Predicted to act upstream of or within cilium assembly; floor plate development; and negative regulation of canonical Wnt signaling pathway. Predicted to be located in centriole; ciliary basal body; and trans-Golgi network. Predicted to be active in nucleus. Orthologous to human CBY1 (chibby 1, beta catenin antagonist). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 143.2), Brain (RPKM 116.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cby1 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (113097220..113103831)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (111216835..111223305)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (120891930..120898318)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene DNA meiotic recombinase 1 Neighboring gene family with sequence similarity 227, member A Neighboring gene uncharacterized LOC134479938 Neighboring gene translocase of outer mitochondrial membrane 22 Neighboring gene Josephin domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structural characterization of partially disordered human Chibby: insights into its function in the Wnt-signaling pathway. Mokhtarzada S, et al. Biochemistry, 2011 Feb 8. PMID 21182262, Free PMC Article
    2. Chibby, an antagonist of the Wnt/beta-catenin pathway, facilitates cardiomyocyte differentiation of murine embryonic stem cells. Singh AM, et al. Circulation, 2007 Feb 6. PMID 17261658, Free PMC Article
    3. PIGEA-14, a novel coiled-coil protein affecting the intracellular distribution of polycystin-2. Hidaka S, et al. J Biol Chem, 2004 Aug 13. PMID 15194699
    4. A Wnt/beta-catenin pathway antagonist Chibby binds Cenexin at the distal end of mother centrioles and functions in primary cilia formation. Steere N, et al. PLoS One, 2012. PMID 22911743, Free PMC Article
    5. Chibby promotes adipocyte differentiation through inhibition of beta-catenin signaling. Li FQ, et al. Mol Cell Biol, 2007 Jun. PMID 17403895, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cardiac muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cardiac muscle cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fat cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within floor plate development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein homotetramerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein chibby homolog 1
    Names
    PIGEA-14
    PKD2 interactor, Golgi and endoplasmic reticulum-associated 1
    PKD2 interactor, golgi and endoplasmic reticulum associated 1
    chibby family member 1, beta catenin antagonist
    chibby homolog 1
    cytosolic leucine-rich protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145676.2 → NP_663709.1  protein chibby homolog 1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      Q8K4I6
      UniProtKB/TrEMBL
      A6HST0
      Conserved Domains (1) summary
      pfam14645
      Location:1 → 114
      Chibby; Chibby family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      113097220..113103831
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078427.2 → XP_038934355.1  protein chibby homolog 1 isoform X1

      UniProtKB/Swiss-Prot
      Q8K4I6
      UniProtKB/TrEMBL
      A6HST0
      Conserved Domains (1) summary
      pfam14645
      Location:1 → 114
      Chibby; Chibby family

    2. XM_006241967.5 → XP_006242029.1  protein chibby homolog 1 isoform X1

      UniProtKB/Swiss-Prot
      Q8K4I6
      UniProtKB/TrEMBL
      A6HST0
      Conserved Domains (1) summary
      pfam14645
      Location:1 → 114
      Chibby; Chibby family

    3. XM_063262997.1 → XP_063119067.1  protein chibby homolog 1 isoform X1

      UniProtKB/Swiss-Prot
      Q8K4I6
      UniProtKB/TrEMBL
      A6HST0
      Related
      ENSRNOP00000105864.1, ENSRNOT00000145467.1

    4. XM_039078426.2 → XP_038934354.1  protein chibby homolog 1 isoform X1

      UniProtKB/Swiss-Prot
      Q8K4I6
      UniProtKB/TrEMBL
      A6HST0
      Conserved Domains (1) summary
      pfam14645
      Location:1 → 114
      Chibby; Chibby family

    5. XM_039078425.2 → XP_038934353.1  protein chibby homolog 1 isoform X1

      UniProtKB/Swiss-Prot
      Q8K4I6
      UniProtKB/TrEMBL
      A6HST0
      Conserved Domains (1) summary
      pfam14645
      Location:1 → 114
      Chibby; Chibby family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K4I6.1 GenPept UniProtKB/Swiss-Prot:Q8K4I6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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