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    Clec10a C-type lectin domain containing 10A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64195, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Clec10aprovided by RGD
    Official Full Name
    C-type lectin domain containing 10Aprovided by RGD
    Primary source
    RGD:621158
    See related
    EnsemblRapid:ENSRNOG00000018715 AllianceGenome:RGD:621158
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mgl; Mgl1; Mgll
    Summary
    Predicted to enable D-mannose binding activity; fucose binding activity; and pattern recognition receptor activity. Predicted to be involved in immune response. Predicted to act upstream of or within connective tissue replacement involved in inflammatory response wound healing. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane. Orthologous to human CLEC10A (C-type lectin domain containing 10A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Uterus (RPKM 149.3), Heart (RPKM 108.1) and 9 other tissues See more
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    Genomic context

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    See Clec10a in Genome Data Viewer
    Location:
    10q24
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (55374914..55379110)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (54876244..54880439)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (56764927..56769447)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene SEC61 translocon subunit gamma like 5 Neighboring gene asialoglycoprotein receptor 2 Neighboring gene solute carrier family 16, member 13 Neighboring gene solute carrier family 16, member 11 Neighboring gene uncharacterized LOC120095129 Neighboring gene BCL6B, transcription repressor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structural similarity between the macrophage lectin specific for galactose/N-acetylgalactosamine and the hepatic asialoglycoprotein binding protein. Ii M, et al. Biochem Biophys Res Commun, 1988 Sep 15. PMID 3421964
    2. Molecular cloning and sequence analysis of cDNA encoding the macrophage lectin specific for galactose and N-acetylgalactosamine. Ii M, et al. J Biol Chem, 1990 Jul 5. PMID 2358462
    3. Segregation of two endocannabinoid-hydrolyzing enzymes into pre- and postsynaptic compartments in the rat hippocampus, cerebellum and amygdala. Gulyas AI, et al. Eur J Neurosci, 2004 Jul. PMID 15233753
    4. Lack of antigen-specific tissue remodeling in mice deficient in the macrophage galactose-type calcium-type lectin 1/CD301a. Sato K, et al. Blood, 2005 Jul 1. PMID 15784728
    5. Effect of nanoformulated copper/zinc superoxide dismutase on chronic ethanol-induced alterations in liver and adipose tissue. Natarajan G, et al. Alcohol, 2019 Sep. PMID 30611703, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MGL is presynaptic enzyme of hippocampus, cerebellum and amygdala.
      Title: Segregation of two endocannabinoid-hydrolyzing enzymes into pre- and postsynaptic compartments in the rat hippocampus, cerebellum and amygdala.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables D-mannose binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fucose binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pattern recognition receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within connective tissue replacement involved in inflammatory response wound healing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    C-type lectin domain family 10 member A
    Names
    C-type lectin domain family 10, member A
    Gal/GalNAc-specific lectin
    M-ASGP-BP
    M-ASGP-BP-1
    MMGL
    macrophage asialoglycoprotein-binding protein 1
    macrophage galactose N-acetyl-galactosamine specific lectin 1
    macrophage galactose/N-acetylgalactosamine-specific lectin
    monoglyceride lipase

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022393.2 → NP_071788.2  C-type lectin domain family 10 member A

      See identical proteins and their annotated locations for NP_071788.2

      Status: PROVISIONAL

      Source sequence(s)
      BC091151
      UniProtKB/Swiss-Prot
      P49301
      UniProtKB/TrEMBL
      A6HG26, F7EKK3, Q5BKA0
      Conserved Domains (3) summary
      cd03590
      Location:175 → 300
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
      pfam01442
      Location:62 → 165
      Apolipoprotein; Apolipoprotein A1/A4/E domain
      pfam03954
      Location:18 → 165
      Lectin_N; Hepatic lectin, N-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      55374914..55379110
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008767868.3 → XP_008766090.1  C-type lectin domain family 10 member A isoform X1

      See identical proteins and their annotated locations for XP_008766090.1

      UniProtKB/Swiss-Prot
      P49301
      Related
      ENSRNOP00000025308.3, ENSRNOT00000025308.6
      Conserved Domains (3) summary
      cd03590
      Location:176 → 301
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
      pfam01442
      Location:63 → 166
      Apolipoprotein; Apolipoprotein A1/A4/E domain
      pfam03954
      Location:21 → 166
      Lectin_N; Hepatic lectin, N-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49301.1 GenPept UniProtKB/Swiss-Prot:P49301

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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