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    Gins1 GINS complex subunit 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499914, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gins1provided by RGD
    Official Full Name
    GINS complex subunit 1provided by RGD
    Primary source
    RGD:1562246
    See related
    EnsemblRapid:ENSRNOG00000008091 AllianceGenome:RGD:1562246
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562246
    Summary
    Predicted to be involved in DNA strand elongation involved in mitotic DNA replication and DNA unwinding involved in DNA replication. Predicted to act upstream of or within DNA replication and inner cell mass cell proliferation. Predicted to be located in cytoplasm and nucleus. Predicted to be part of CMG complex and GINS complex. Human ortholog(s) of this gene implicated in immunodeficiency 55. Orthologous to human GINS1 (GINS complex subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 98.5), Spleen (RPKM 61.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gins1 in Genome Data Viewer
    Location:
    3q41
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (160184920..160206334)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (139724513..139745930)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (146695366..146716787)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene abhydrolase domain containing 12, lysophospholipase Neighboring gene uncharacterized LOC134486181 Neighboring gene uncharacterized LOC120101747 Neighboring gene activator of basal transcription 1, pseudogene 2 Neighboring gene RNA, U6 small nuclear 722 Neighboring gene ninein-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. PSF1 is essential for early embryogenesis in mice. Ueno M, et al. Mol Cell Biol, 2005 Dec. PMID 16287864, Free PMC Article
    2. Identification and characterization of mouse PSF1-binding protein, SLD5. Kong L, et al. Biochem Biophys Res Commun, 2006 Jan 27. PMID 16338220
    3. A visual intracellular classification strategy for uncharacterized human proteins. Hoja MR, et al. Exp Cell Res, 2000 Aug 25. PMID 10942595
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA unwinding involved in DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within inner cell mass cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of CMG complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of GINS complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DNA replication complex GINS protein PSF1
    Names
    GINS complex subunit 1 (Psf1 homolog)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109207.2 → NP_001102677.2  DNA replication complex GINS protein PSF1

      See identical proteins and their annotated locations for NP_001102677.2

      Status: VALIDATED

      Source sequence(s)
      BC166989
      UniProtKB/TrEMBL
      A6KHH3, B2RZ16, F7EXT9
      Related
      ENSRNOP00000010955.3, ENSRNOT00000010955.7
      Conserved Domains (2) summary
      cd11710
      Location:3 → 130
      GINS_A_psf1; Alpha-helical domain of GINS complex protein Psf1
      COG5230
      Location:1 → 191
      COG5230; Uncharacterized conserved protein [Function unknown]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      160184920..160206334
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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