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    Mif macrophage migration inhibitory factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81683, updated on 9-Dec-2024

    Summary

    Symbol
    Mifprovided by RGD
    Full Name
    macrophage migration inhibitory factorprovided by RGD
    Primary source
    RGD:621163
    See related
    AllianceGenome:RGD:621163
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including identical protein binding activity; intramolecular oxidoreductase activity; and receptor ligand activity. Involved in several processes, including brain renin-angiotensin system; positive regulation of glycolytic process; and positive regulation of transport. Located in extracellular space. Used to study several diseases, including acute necrotizing pancreatitis; cardiomyopathy (multiple); lung disease (multiple); retinitis; and toxic shock syndrome. Biomarker of borna disease; cystitis; kidney disease; myocardial infarction; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in allergic disease; asthma; cystic fibrosis; lung disease (multiple); and obesity. Orthologous to human MIF (macrophage migration inhibitory factor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 573.4), Brain (RPKM 421.3) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Mif in Genome Data Viewer
    Location:
    20p12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (12767138..12791222)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (12790919..12791784)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (13715219..13732980)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene SWI/SNF related BAF chromatin remodeling complex subunit B1 Neighboring gene uncharacterized LOC134483889 Neighboring gene derlin 3 Neighboring gene uncharacterized LOC134483888 Neighboring gene glutathione S-transferase theta 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC72801

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chemoattractant activity  
    enables cytokine activity  
    enables cytokine activity  
    enables cytokine activity  
    enables cytokine receptor binding  
    enables dopachrome isomerase activity  
    enables dopachrome isomerase activity  
    enables identical protein binding  
    enables isomerase activity  
    enables phenylpyruvate tautomerase activity  
    enables phenylpyruvate tautomerase activity  
    enables protease binding  
    enables protein-containing complex binding PubMed 
    Items 1 - 25 of 60
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response, signal transduction by p53 class mediator  
    involved_in brain renin-angiotensin system PubMed 
    involved_in carboxylic acid metabolic process  
    involved_in cell surface receptor signaling pathway  
    involved_in cellular response to hydrogen peroxide PubMed 
    involved_in cellular response to hypoxia PubMed 
    acts_upstream_of_or_within cellular senescence  
    involved_in drinking behavior PubMed 
    involved_in hair follicle development PubMed 
    involved_in inflammatory response  
    involved_in innate immune response  
    involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of cell migration  
    involved_in negative regulation of cellular senescence  
    involved_in negative regulation of gene expression  
    involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  
    involved_in negative regulation of macrophage chemotaxis  
    involved_in negative regulation of mature B cell apoptotic process  
    involved_in negative regulation of myeloid cell apoptotic process  
    involved_in negative regulation of protein metabolic process  
    involved_in positive chemotaxis  
    involved_in positive regulation of B cell proliferation  
    involved_in positive regulation of D-glucose import PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade  
    involved_in positive regulation of MAP kinase activity  
    involved_in positive regulation of acute inflammatory response PubMed 
    involved_in positive regulation of arachidonate secretion  
    involved_in positive regulation of axon regeneration PubMed 
    involved_in positive regulation of cAMP/PKA signal transduction  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of chemokine (C-X-C motif) ligand 2 production  
    involved_in positive regulation of cytokine production  
    involved_in positive regulation of fibroblast proliferation  
    involved_in positive regulation of glycolytic process PubMed 
    involved_in positive regulation of immune response PubMed 
    involved_in positive regulation of lipopolysaccharide-mediated signaling pathway  
    involved_in positive regulation of myeloid leukocyte cytokine production involved in immune response  
    involved_in positive regulation of phosphorylation  
    involved_in positive regulation of potassium ion transport PubMed 
    involved_in positive regulation of prostaglandin secretion involved in immune response  
    involved_in positive regulation of protein phosphorylation  
    involved_in positive regulation of smooth muscle cell migration PubMed 
    involved_in positive regulation of tumor necrosis factor production  
    involved_in prostaglandin biosynthetic process  
    involved_in protein homotrimerization  
    acts_upstream_of_or_within regulation of cell population proliferation  
    involved_in response to estradiol PubMed 
    involved_in response to glucocorticoid PubMed 
    involved_in response to hormone PubMed 
    involved_in response to insulin PubMed 
    involved_in response to lipopolysaccharide PubMed 
    involved_in response to mechanical stimulus PubMed 
    involved_in response to menaquinone PubMed 
    involved_in response to progesterone PubMed 
    involved_in response to vitamin E PubMed 
    involved_in response to xenobiotic stimulus PubMed 
    involved_in signal transduction  
    involved_in skin development PubMed 
    involved_in spermatogenesis PubMed 
    Items 1 - 25 of 60
    Component Evidence Code Pubs
    located_in cell surface  
    located_in cytoplasm  
    located_in cytosol  
    located_in extracellular region  
    is_active_in extracellular space  
    located_in extracellular space PubMed 
    located_in extracellular space  
    located_in extracellular space  
    located_in nucleoplasm  
    located_in plasma membrane  

    General protein information

    Preferred Names
    macrophage migration inhibitory factor
    Names
    L-dopachrome isomerase
    L-dopachrome tautomerase
    glutathione-binding 13 kDa protein
    macrophage migration inhibitory factor (glycosylation-inhibiting factor)
    phenylpyruvate tautomerase
    NP_112313.1
    XP_063135631.1
    XP_063135632.1
    XP_063135633.1
    XP_063135634.1
    XP_063135635.1
    XP_063135636.1
    XP_063135637.1
    XP_063135638.1
    XP_063135639.1
    XP_063135640.1
    XP_063135641.1
    XP_063135642.1
    XP_063135643.1
    XP_063135644.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031051.2NP_112313.1  macrophage migration inhibitory factor

      See identical proteins and their annotated locations for NP_112313.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/Swiss-Prot
      P30904
      UniProtKB/TrEMBL
      A0A0F7RQL3, D4A3P7
      Conserved Domains (1) summary
      pfam01187
      Location:2115
      MIF; Macrophage migration inhibitory factor (MIF)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      12767138..12791222
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279572.1XP_063135642.1  macrophage migration inhibitory factor isoform X2

      UniProtKB/Swiss-Prot
      P30904
      UniProtKB/TrEMBL
      A0A0F7RQL3, D4A3P7
    2. XM_063279566.1XP_063135636.1  macrophage migration inhibitory factor isoform X2

      UniProtKB/Swiss-Prot
      P30904
      UniProtKB/TrEMBL
      A0A0F7RQL3, D4A3P7
    3. XM_063279565.1XP_063135635.1  macrophage migration inhibitory factor isoform X2

      UniProtKB/Swiss-Prot
      P30904
      UniProtKB/TrEMBL
      A0A0F7RQL3, D4A3P7
    4. XM_063279570.1XP_063135640.1  macrophage migration inhibitory factor isoform X2

      UniProtKB/Swiss-Prot
      P30904
      UniProtKB/TrEMBL
      A0A0F7RQL3, D4A3P7
    5. XM_063279571.1XP_063135641.1  macrophage migration inhibitory factor isoform X2

      UniProtKB/Swiss-Prot
      P30904
      UniProtKB/TrEMBL
      A0A0F7RQL3, D4A3P7
    6. XM_063279567.1XP_063135637.1  macrophage migration inhibitory factor isoform X2

      UniProtKB/Swiss-Prot
      P30904
      UniProtKB/TrEMBL
      A0A0F7RQL3, D4A3P7
    7. XM_063279564.1XP_063135634.1  macrophage migration inhibitory factor isoform X1

    8. XM_063279568.1XP_063135638.1  macrophage migration inhibitory factor isoform X2

      UniProtKB/Swiss-Prot
      P30904
      UniProtKB/TrEMBL
      A0A0F7RQL3, D4A3P7
    9. XM_063279561.1XP_063135631.1  macrophage migration inhibitory factor isoform X1

    10. XM_063279574.1XP_063135644.1  macrophage migration inhibitory factor isoform X2

      UniProtKB/Swiss-Prot
      P30904
      UniProtKB/TrEMBL
      A0A0F7RQL3, D4A3P7
    11. XM_063279562.1XP_063135632.1  macrophage migration inhibitory factor isoform X1

    12. XM_063279563.1XP_063135633.1  macrophage migration inhibitory factor isoform X1

    13. XM_063279569.1XP_063135639.1  macrophage migration inhibitory factor isoform X2

      UniProtKB/Swiss-Prot
      P30904
      UniProtKB/TrEMBL
      A0A0F7RQL3, D4A3P7
    14. XM_063279573.1XP_063135643.1  macrophage migration inhibitory factor isoform X2

      UniProtKB/Swiss-Prot
      P30904
      UniProtKB/TrEMBL
      A0A0F7RQL3, D4A3P7
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