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    Polq DNA polymerase theta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288079, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Polqprovided by RGD
    Official Full Name
    DNA polymerase thetaprovided by RGD
    Primary source
    RGD:1309795
    See related
    EnsemblRapid:ENSRNOG00000002471 AllianceGenome:RGD:1309795
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including catalytic activity, acting on DNA; identical protein binding activity; and magnesium ion binding activity. Predicted to be involved in several processes, including DNA metabolic process; negative regulation of double-strand break repair via homologous recombination; and somatic hypermutation of immunoglobulin genes. Predicted to act upstream of or within DNA repair. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Predicted to be active in mitochondrial nucleoid; nucleus; and site of double-strand break. Orthologous to human POLQ (DNA polymerase theta). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 43.6), Spleen (RPKM 34.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Polq in Genome Data Viewer
    Location:
    11q21
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (77179190..77281270, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (63673796..63775905, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (66585860..66695369, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene RAB, member of RAS oncogene family-like 3 Neighboring gene general transcription factor IIE subunit 1 Neighboring gene U2 spliceosomal RNA Neighboring gene syntaxin binding protein 5L Neighboring gene ring finger protein 138, pseudogene 4 Neighboring gene G protein subunit gamma 10, pseudogene 1 Neighboring gene F-box protein 40 Neighboring gene hematopoietic cell specific Lyn substrate 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway. Newman JA, et al. Structure, 2015 Dec 1. PMID 26636256, Free PMC Article
    2. Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase θ. Kent T, et al. Nat Struct Mol Biol, 2015 Mar. PMID 25643323, Free PMC Article
    3. Promiscuous DNA synthesis by human DNA polymerase θ. Hogg M, et al. Nucleic Acids Res, 2012 Mar. PMID 22135286, Free PMC Article
    4. Human DNA polymerase theta possesses 5'-dRP lyase activity and functions in single-nucleotide base excision repair in vitro. Prasad R, et al. Nucleic Acids Res, 2009 Apr. PMID 19188258, Free PMC Article
    5. Absence of DNA polymerase theta results in decreased somatic hypermutation frequency and altered mutation patterns in Ig genes. Masuda K, et al. DNA Repair (Amst), 2006 Nov 8. PMID 16890500

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 5'-deoxyribose-5-phosphate lyase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-directed DNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-directed DNA polymerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables single-stranded DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in base-excision repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in double-strand break repair via alternative nonhomologous end joining IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair via alternative nonhomologous end joining ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in error-prone translesion synthesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in replication fork processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in somatic hypermutation of immunoglobulin genes ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrial nucleoid ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in site of DNA damage ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DNA polymerase theta
    Names
    polymerase (DNA directed), theta
    polymerase (DNA) theta
    NP_001099348.1
    XP_038944052.1
    XP_038944053.1
    XP_038944054.2
    XP_063126449.1
    XP_063126450.1
    XP_063126451.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105878.1 → NP_001099348.1  DNA polymerase theta

      See identical proteins and their annotated locations for NP_001099348.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473967
      UniProtKB/TrEMBL
      A6IR96, D4A628
      Related
      ENSRNOP00000061230.1, ENSRNOT00000063995.3
      Conserved Domains (6) summary
      cd08638
      Location:2050 → 2542
      DNA_pol_A_theta; DNA polymerase theta is a low-fidelity family A enzyme implicated in translesion synthesis and in somatic hypermutation
      smart00490
      Location:413 → 486
      HELICc; helicase superfamily c-terminal domain
      COG0749
      Location:1857 → 2543
      PolA; DNA polymerase I - 3'-5' exonuclease and polymerase domains [Replication, recombination and repair]
      PRK02362
      Location:77 → 832
      PRK02362; ski2-like helicase; Provisional
      pfam00270
      Location:97 → 270
      DEAD; DEAD/DEAH box helicase
      cl10012
      Location:1844 → 2044
      DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      77179190..77281270 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270379.1 → XP_063126449.1  DNA polymerase theta isoform X1

    2. XM_039088124.2 → XP_038944052.1  DNA polymerase theta isoform X3

      Conserved Domains (3) summary
      cd08638
      Location:1878 → 2370
      DNA_pol_A_theta; DNA polymerase theta is a low-fidelity family A enzyme implicated in translesion synthesis and in somatic hypermutation
      PRK02362
      Location:14 → 660
      PRK02362; ATP-dependent DNA helicase
      cl10012
      Location:1672 → 1872
      DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

    3. XM_039088126.2 → XP_038944054.2  DNA polymerase theta isoform X5

    4. XM_063270381.1 → XP_063126451.1  DNA polymerase theta isoform X6

    5. XM_063270380.1 → XP_063126450.1  DNA polymerase theta isoform X2

    6. XM_039088125.2 → XP_038944053.1  DNA polymerase theta isoform X4

      Conserved Domains (3) summary
      COG1204
      Location:77 → 830
      BRR2; Replicative superfamily II helicase [Replication, recombination and repair]
      PRK05755
      Location:1857 → 2116
      PRK05755; DNA polymerase I; Provisional
      cd18026
      Location:77 → 290
      DEXHc_POLQ-like; DEXH-box helicase domain of DNA polymerase theta

    RNA

    1. XR_005491001.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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