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    Myh7b myosin heavy chain 7B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311570, updated on 9-Dec-2024

    Summary

    Official Symbol
    Myh7bprovided by RGD
    Official Full Name
    myosin heavy chain 7Bprovided by RGD
    Primary source
    RGD:1307994
    See related
    EnsemblRapid:ENSRNOG00000018997 AllianceGenome:RGD:1307994
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable actin filament binding activity and microfilament motor activity. Involved in regulation of CAMKK-AMPK signaling cascade; regulation of cardiac muscle cell contraction; and regulation of cytosolic calcium ion concentration. Predicted to be located in cardiac myofibril. Predicted to be part of myosin II complex. Predicted to be active in cytoplasm and myosin filament. Used to study hypertrophic cardiomyopathy. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy. Orthologous to human MYH7B (myosin heavy chain 7B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 126.2), Kidney (RPKM 60.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Myh7b in Genome Data Viewer
    Location:
    3q42
    Exon count:
    43
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (164537211..164582441)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (144076911..144122714)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (151105038..151150621)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene gamma-glutamyltransferase 7 Neighboring gene small nucleolar RNA SNORA18 Neighboring gene acyl-CoA synthetase short-chain family member 2 Neighboring gene glutathione synthetase Neighboring gene microRNA 499a Neighboring gene transient receptor potential cation channel, subfamily C, member 4 associated protein Neighboring gene ER degradation enhancing alpha-mannosidase like protein 2 Neighboring gene protein C receptor

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables actin filament binding  
    enables microfilament motor activity  
    Component Evidence Code Pubs
    located_in cardiac myofibril  
    is_active_in cytoplasm  
    part_of myosin II complex  
    is_active_in myosin filament  

    General protein information

    Preferred Names
    myosin-7B
    Names
    myosin, heavy chain 7B, cardiac muscle, beta
    myosin, heavy polypeptide 7B, cardiac muscle, beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107794.2NP_001101264.2  myosin-7B

      See identical proteins and their annotated locations for NP_001101264.2

      Status: PROVISIONAL

      Source sequence(s)
      EU241478
      UniProtKB/TrEMBL
      B6RK61
      Related
      ENSRNOP00000106404.1, ENSRNOT00000148538.1
      Conserved Domains (3) summary
      cd14927
      Location:98773
      MYSc_Myh7b; class II myosin heavy chain 7b, motor domain
      pfam01576
      Location:8531930
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:3271
      Myosin_N; Myosin N-terminal SH3-like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      164537211..164582441
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039105078.2XP_038961006.1  myosin-7B isoform X1

      UniProtKB/TrEMBL
      B6RK61
      Conserved Domains (3) summary
      cd14927
      Location:98773
      MYSc_Myh7b; class II myosin heavy chain 7b, motor domain
      pfam01576
      Location:8531930
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:3271
      Myosin_N; Myosin N-terminal SH3-like domain
    2. XM_039105079.2XP_038961007.1  myosin-7B isoform X2

      Conserved Domains (3) summary
      cd14927
      Location:98773
      MYSc_Myh7b; class II myosin heavy chain 7b, motor domain
      pfam01576
      Location:8531930
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:3271
      Myosin_N; Myosin N-terminal SH3-like domain
    3. XM_017591783.3XP_017447272.1  myosin-7B isoform X1

      UniProtKB/TrEMBL
      B6RK61
      Conserved Domains (3) summary
      cd14927
      Location:98773
      MYSc_Myh7b; class II myosin heavy chain 7b, motor domain
      pfam01576
      Location:8531930
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:3271
      Myosin_N; Myosin N-terminal SH3-like domain
    4. XM_039105080.2XP_038961008.1  myosin-7B isoform X3

      Conserved Domains (2) summary
      pfam01576
      Location:6241701
      Myosin_tail_1; Myosin tail
      cl22853
      Location:1544
      Motor_domain; Myosin and Kinesin motor domain
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