Kcnab2 potassium voltage-gated channel subfamily A regulatory beta subunit 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kcnab2provided by RGD
Official Full Name: potassium voltage-gated channel subfamily A regulatory beta subunit 2provided by RGD
Primary source: RGD:61828
See related: EnsemblRapid:ENSRNOG00000011550 AllianceGenome:RGD:61828
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables aldo-keto reductase (NADPH) activity; potassium channel regulator activity; and transmembrane transporter binding activity. Involved in several processes, including NADPH oxidation; myoblast differentiation; and regulation of protein localization to cell surface. Located in several cellular components, including axon; cytoplasmic side of plasma membrane; and microtubule. Part of potassium channel complex. Is active in glutamatergic synapse and postsynaptic density membrane. Orthologous to human KCNAB2 (potassium voltage-gated channel subfamily A regulatory beta subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 249.8), Thymus (RPKM 121.4) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (168182228..168270760, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (162899511..162988057, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (169570327..169658875, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that potassium channel Kvbeta2 inhibitors could serve as tools to decipher the role of Kvbeta2 in vivo and, eventually, inform the development of novel therapeutics.
Title: New inhibitors of the Kvβ2 subunit from mammalian Kv1 potassium channels.
Article reports a newly identified protein-protein interaction between the PSD-protein ProSAP2/Shank3 and the voltage-gated potassium channel subunit Kvbeta2
Title: The Kvβ2 subunit of voltage-gated potassium channels is interacting with ProSAP2/Shank3 in the PSD.
Kvbeta2 catalyzed the NADPH-dependent reduction of several products of oxPAPC
Title: Catalytic reduction of carbonyl groups in oxidized PAPC by Kvβ2 (AKR6).
ZIP3 formed dimers with ZIP1-3 and interacted with PKC-zeta and the shaker-type potassium channel subunit Kv beta 2
Title: ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2.
identification of Kvbeta2 substrates and the demonstration that Kvbeta2 is a functional aldo-keto reductase
Title: Modulation of voltage-dependent Shaker family potassium channels by an aldo-keto reductase.
There is a possibility that the K+ voltage-gated channel function is modulated by its beta-subunit.
Title: Conformational changes in the C terminus of Shaker K+ channel bound to the rat Kvbeta2-subunit.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH138171 (e-PCR)
- UniSTS:220258

RH94672 (e-PCR)
- UniSTS:119919

BE103035 (e-PCR)
- UniSTS:244734

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables aldo-keto reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables aldo-keto reductase (NADPH) activity	IDA Inferred from Direct Assay more info	PubMed
enables methylglyoxal reductase (NADPH) (acetol producing) activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables potassium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium channel regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables potassium channel regulator activity	IEA Inferred from Electronic Annotation more info
enables potassium channel regulator activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed
enables voltage-gated potassium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in NADPH oxidation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in myoblast differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in neuromuscular process	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of potassium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein localization to cell surface	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IEA Inferred from Electronic Annotation more info
located_in axon	ISO Inferred from Sequence Orthology more info
is_active_in axon initial segment	ISO Inferred from Sequence Orthology more info
located_in axon terminus	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in juxtaparanode region of axon	IBA Inferred from Biological aspect of Ancestor more info
located_in juxtaparanode region of axon	IDA Inferred from Direct Assay more info	PubMed
located_in juxtaparanode region of axon	IEA Inferred from Electronic Annotation more info
located_in juxtaparanode region of axon	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in pinceau fiber	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density membrane	IMP Inferred from Mutant Phenotype more info	PubMed
part_of potassium channel complex	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IEA Inferred from Electronic Annotation more info
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: voltage-gated potassium channel subunit beta-2

Names: K(+) channel subunit beta-2; kv-beta-2; potassium channel, voltage gated shaker-related subfamily A regulatory beta subunit 2; potassium channel, voltage gated subfamily A regulatory beta subunit 2; potassium voltage-gated channel, shaker-related subfamily, beta member 2

NP_059000.1

EC 1.1.1.-

XP_017448703.1

EC 1.1.1.-

XP_017448704.1

EC 1.1.1.-

XP_038965314.1

EC 1.1.1.-

XP_063143337.1

EC 1.1.1.-

XP_063143338.1

EC 1.1.1.-

XP_063143339.1

EC 1.1.1.-

XP_063143340.1

EC 1.1.1.-

XP_063143341.1

EC 1.1.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429742.1 → NP_001416671.1 voltage-gated potassium channel subunit beta-2 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A0A0G2K670
NM_001429743.1 → NP_001416672.1 voltage-gated potassium channel subunit beta-2 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A0A0G2K670
NM_001429744.1 → NP_001416673.1 voltage-gated potassium channel subunit beta-2 isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A0A8I5ZVX6, A0A8L2Q7L3
NM_001429745.1 → NP_001416674.1 voltage-gated potassium channel subunit beta-2 isoform 4

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A0A8I5ZVX6
NM_001429746.1 → NP_001416675.1 voltage-gated potassium channel subunit beta-2 isoform 5

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P62483

UniProtKB/TrEMBL

A0A8I5ZVX6, A6IUI6
NM_001429747.1 → NP_001416676.1 voltage-gated potassium channel subunit beta-2 isoform 6

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A0A8I5ZVX6, A0A8I6GCY0
NM_001429748.1 → NP_001416677.1 voltage-gated potassium channel subunit beta-2 isoform 6

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A0A8I5ZVX6, A0A8I6GCY0
NM_017304.3 → NP_059000.1 voltage-gated potassium channel subunit beta-2 isoform 5

See identical proteins and their annotated locations for NP_059000.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P62483

UniProtKB/TrEMBL

A0A8I5ZVX6, A6IUI6

Related

ENSRNOP00000085478.2, ENSRNOT00000101700.2

Conserved Domains (1) summary

cd19141
Location:38 → 347

Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

168182228..168270760 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017593214.3 → XP_017448703.1 voltage-gated potassium channel subunit beta-2 isoform X1

Related

ENSRNOP00000015840.3, ENSRNOT00000015840.5

Conserved Domains (1) summary

cd19141
Location:38 → 363

Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)
XM_039109386.2 → XP_038965314.1 voltage-gated potassium channel subunit beta-2 isoform X6

UniProtKB/TrEMBL

A0A8I5ZVX6

Conserved Domains (1) summary

cl00470
Location:1 → 296

AKR_SF; Aldo-keto reductase (AKR) superfamily
XM_063287270.1 → XP_063143340.1 voltage-gated potassium channel subunit beta-2 isoform X5

Related

ENSRNOP00000082892.2, ENSRNOT00000111948.2
XM_063287268.1 → XP_063143338.1 voltage-gated potassium channel subunit beta-2 isoform X3

UniProtKB/TrEMBL

A0A8I5ZVX6

Related

ENSRNOP00000081886.1, ENSRNOT00000113173.2
XM_063287269.1 → XP_063143339.1 voltage-gated potassium channel subunit beta-2 isoform X4
XM_063287267.1 → XP_063143337.1 voltage-gated potassium channel subunit beta-2 isoform X2

UniProtKB/TrEMBL

A0A8I5ZVX6
XM_017593215.3 → XP_017448704.1 voltage-gated potassium channel subunit beta-2 isoform X1

UniProtKB/TrEMBL

A0A8I5ZVX6, A0A8L2Q7L3

Conserved Domains (1) summary

cd19141
Location:38 → 363

Aldo_ket_red_shaker; Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR)
XM_063287271.1 → XP_063143341.1 voltage-gated potassium channel subunit beta-2 isoform X7