Dusp29 dual specificity phosphatase 29 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dusp29provided by RGD
Official Full Name: dual specificity phosphatase 29provided by RGD
Primary source: RGD:1310229
See related: EnsemblRapid:ENSRNOG00000013034 AllianceGenome:RGD:1310229
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dupd1
Summary: Predicted to enable MAP kinase phosphatase activity; protein homodimerization activity; and protein tyrosine/serine/threonine phosphatase activity. Predicted to be involved in several processes, including glucose homeostasis; negative regulation of ERK1 and ERK2 cascade; and protein dephosphorylation. Predicted to be located in nucleus. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Orthologous to human DUSP29 (dual specificity phosphatase 29). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 145.9) See more
Orthologs: human mouse all
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Genomic context

Location:: 15p16

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (2642809..2682850)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (2593473..2634019)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (2766929..2806573)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables MAP kinase phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables MAP kinase phosphatase activity	ISO Inferred from Sequence Orthology more info
enables MAP kinase phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables MAP kinase serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables calmodulin-dependent protein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS140 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXY142 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity, metal-dependent	IEA Inferred from Electronic Annotation more info
enables protein tyrosine/serine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine/serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine/serine/threonine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine/serine/threonine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in muscle cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein dephosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dual specificity phosphatase 29

Names: dual specificity phosphatase DUPD1; dual specificity phosphatase and pro isomerase domain containing 1

NP_001101838.1

EC 3.1.3.16

EC 3.1.3.48

XP_017455221.1

EC 3.1.3.16

EC 3.1.3.48

XP_063130436.1

EC 3.1.3.16

EC 3.1.3.48

XP_063130437.1

EC 3.1.3.16

EC 3.1.3.48

XP_063130438.1

EC 3.1.3.16

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108368.1 → NP_001101838.1 dual specificity phosphatase 29

See identical proteins and their annotated locations for NP_001101838.1

Status: PROVISIONAL

Source sequence(s)

CH474061

UniProtKB/Swiss-Prot

P0C595

UniProtKB/TrEMBL

A6KKS6

Related

ENSRNOP00000017483.4, ENSRNOT00000017483.7

Conserved Domains (1) summary

cd14575
Location:44 → 203

DUPD1; dual specificity phosphatase and pro isomerase domain containing 1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

2642809..2682850

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063274368.1 → XP_063130438.1 dual specificity phosphatase 29 isoform X3

UniProtKB/TrEMBL

A0A8I6AGT7
XM_063274366.1 → XP_063130436.1 dual specificity phosphatase 29 isoform X1

UniProtKB/Swiss-Prot

P0C595

UniProtKB/TrEMBL

A6KKS6
XM_017599732.3 → XP_017455221.1 dual specificity phosphatase 29 isoform X1

UniProtKB/Swiss-Prot

P0C595

UniProtKB/TrEMBL

A6KKS6

Conserved Domains (1) summary

cd14575
Location:44 → 203

DUPD1; dual specificity phosphatase and pro isomerase domain containing 1
XM_063274367.1 → XP_063130437.1 dual specificity phosphatase 29 isoform X2

Related

ENSRNOP00000110191.1, ENSRNOT00000124521.1