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    Fto FTO, alpha-ketoglutarate dependent dioxygenase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291905, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ftoprovided by RGD
    Official Full Name
    FTO, alpha-ketoglutarate dependent dioxygenaseprovided by RGD
    Primary source
    RGD:1305121
    See related
    EnsemblRapid:ENSRNOG00000011728 AllianceGenome:RGD:1305121
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305121
    Summary
    Predicted to enable 2-oxoglutarate-dependent dioxygenase activity and ferrous iron binding activity. Involved in several processes, including negative regulation of eating behavior; positive regulation of insulin secretion involved in cellular response to glucose stimulus; and response to bisphenol A. Predicted to be located in cytosol; nuclear speck; and plasma membrane. Used to study sciatic neuropathy. Biomarker of metabolic dysfunction-associated steatotic liver disease; obesity; transient cerebral ischemia; traumatic brain injury; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); diabetic neuropathy; nuclear senile cataract; renal cell carcinoma (multiple); and type 2 diabetes mellitus. Orthologous to human FTO (FTO alpha-ketoglutarate dependent dioxygenase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 136.3), Kidney (RPKM 111.9) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Fto in Genome Data Viewer
    Location:
    19p11
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (31456749..31865011, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (15284898..15692142, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (16774549..17115098, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483614 Neighboring gene iroquois homeobox 3 Neighboring gene uncharacterized LOC102556484 Neighboring gene Rpgrip1-like Neighboring gene uncharacterized LOC134483615

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 2-oxoglutarate-dependent dioxygenase activity  
    enables broad specificity oxidative DNA demethylase activity  
    enables broad specificity oxidative DNA demethylase activity  
    enables broad specificity oxidative DNA demethylase activity  
    enables broad specificity oxidative DNA demethylase activity  
    enables ferrous iron binding  
    enables ferrous iron binding  
    enables ferrous iron binding  
    enables ferrous iron binding  
    enables mRNA N6-methyladenosine dioxygenase activity  
    enables mRNA N6-methyladenosine dioxygenase activity  
    enables mRNA N6-methyladenosine dioxygenase activity  
    enables mRNA N6-methyladenosine dioxygenase activity  
    enables molecular_function  
    enables oxidative RNA demethylase activity  
    enables oxidative RNA demethylase activity  
    enables tRNA demethylase activity  
    enables tRNA demethylase activity  
    enables tRNA demethylase activity  
    Items 1 - 25 of 32
    Process Evidence Code Pubs
    involved_in DNA alkylation repair  
    involved_in DNA alkylation repair  
    involved_in RNA repair  
    involved_in RNA repair  
    involved_in adipose tissue development  
    involved_in adipose tissue development  
    involved_in heart development PubMed 
    involved_in mRNA destabilization  
    involved_in mRNA destabilization  
    involved_in mRNA destabilization  
    involved_in negative regulation of eating behavior PubMed 
    involved_in osteoblast differentiation PubMed 
    involved_in positive regulation of apoptotic process PubMed 
    involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus PubMed 
    involved_in regulation of brown fat cell differentiation  
    involved_in regulation of brown fat cell differentiation  
    involved_in regulation of cytosolic calcium ion concentration PubMed 
    involved_in regulation of lipid storage  
    involved_in regulation of lipid storage  
    involved_in regulation of multicellular organism growth  
    involved_in regulation of multicellular organism growth  
    involved_in regulation of respiratory system process  
    involved_in regulation of respiratory system process  
    involved_in regulation of white fat cell proliferation  
    involved_in regulation of white fat cell proliferation  
    involved_in response to bisphenol A PubMed 
    involved_in response to nutrient levels PubMed 
    involved_in sensory perception of pain PubMed 
    involved_in snRNA processing  
    involved_in snRNA processing  
    involved_in temperature homeostasis  
    involved_in temperature homeostasis  
    Items 1 - 25 of 32
    Component Evidence Code Pubs
    is_active_in cellular_component  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in intracellular membrane-bounded organelle  
    located_in nuclear speck  
    located_in nuclear speck  
    located_in nuclear speck  
    located_in nucleus  
    located_in nucleus  
    located_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    alpha-ketoglutarate-dependent dioxygenase FTO
    Names
    U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO
    U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO
    fat mass and obesity associated
    fat mass and obesity-associated protein
    m6A(m)-demethylase FTO
    mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO
    mRNA N(6)-methyladenosine demethylase FTO
    protein fto
    tRNA N1-methyl adenine demethylase FTO
    NP_001034802.1
    XP_038953492.1
    XP_038953493.1
    XP_038953494.1
    XP_038953495.1
    XP_038953496.1
    XP_063133931.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039713.1NP_001034802.1  alpha-ketoglutarate-dependent dioxygenase FTO

      See identical proteins and their annotated locations for NP_001034802.1

      Status: PROVISIONAL

      Source sequence(s)
      AM233906
      UniProtKB/Swiss-Prot
      Q2A121
      UniProtKB/TrEMBL
      A0A0G2K675, B4F7E0
      Related
      ENSRNOP00000015718.4, ENSRNOT00000015718.8
      Conserved Domains (2) summary
      pfam12933
      Location:36322
      FTO_NTD; FTO catalytic domain
      pfam12934
      Location:326495
      FTO_CTD; FTO C-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      31456749..31865011 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097565.2XP_038953493.1  alpha-ketoglutarate-dependent dioxygenase FTO isoform X2

      UniProtKB/TrEMBL
      A0A0G2K675
      Conserved Domains (2) summary
      pfam12933
      Location:36322
      FTO_NTD; FTO catalytic domain
      pfam12934
      Location:326452
      FTO_CTD; FTO C-terminal domain
    2. XM_039097564.2XP_038953492.1  alpha-ketoglutarate-dependent dioxygenase FTO isoform X1

      UniProtKB/TrEMBL
      A0A0G2K675
      Conserved Domains (2) summary
      pfam12933
      Location:36322
      FTO_NTD; FTO catalytic domain
      pfam12934
      Location:326453
      FTO_CTD; FTO C-terminal domain
    3. XM_039097566.2XP_038953494.1  alpha-ketoglutarate-dependent dioxygenase FTO isoform X3

      Conserved Domains (2) summary
      pfam12933
      Location:6151
      FTO_NTD; FTO catalytic domain
      pfam12934
      Location:155323
      FTO_CTD; FTO C-terminal domain
    4. XM_063277861.1XP_063133931.1  alpha-ketoglutarate-dependent dioxygenase FTO isoform X3

    5. XM_039097568.2XP_038953496.1  alpha-ketoglutarate-dependent dioxygenase FTO isoform X3

      Conserved Domains (2) summary
      pfam12933
      Location:6151
      FTO_NTD; FTO catalytic domain
      pfam12934
      Location:155323
      FTO_CTD; FTO C-terminal domain
    6. XM_039097567.2XP_038953495.1  alpha-ketoglutarate-dependent dioxygenase FTO isoform X3

      Conserved Domains (2) summary
      pfam12933
      Location:6151
      FTO_NTD; FTO catalytic domain
      pfam12934
      Location:155323
      FTO_CTD; FTO C-terminal domain
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