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    Ptprt protein tyrosine phosphatase, receptor type, T [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362263, updated on 9-Dec-2024

    Summary

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    Symbol
    Ptprtprovided by RGD
    Full Name
    protein tyrosine phosphatase, receptor type, Tprovided by RGD
    Primary source
    RGD:1309653
    See related
    EnsemblRapid:ENSRNOG00000032656 AllianceGenome:RGD:1309653
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including STAT family protein binding activity; alpha-catenin binding activity; and beta-catenin binding activity. Involved in regulation of synapse organization. Is active in glutamatergic synapse and postsynaptic density membrane. Human ortholog(s) of this gene implicated in colorectal cancer and esophagus squamous cell carcinoma. Orthologous to human PTPRT (protein tyrosine phosphatase receptor type T). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 112.0), Spleen (RPKM 11.2) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ptprt in Genome Data Viewer
    Location:
    3q42
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (170608993..171707692, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (150189343..151288145, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (157537192..158328984, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108350515 Neighboring gene uncharacterized LOC120101777 Neighboring gene uncharacterized LOC134486201 Neighboring gene U2 small nuclear ribonucleoprotein B''-like Neighboring gene uncharacterized LOC120101926 Neighboring gene uncharacterized LOC120101925 Neighboring gene uncharacterized LOC134486308 Neighboring gene uncharacterized LOC102547303

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. PTPRT and PTPRD Deleterious Mutations and Deletion Predict Bevacizumab Resistance in Metastatic Colorectal Cancer Patients. Hsu HC, et al. Cancers (Basel), 2018 Sep 6. PMID 30200630, Free PMC Article
    2. Regulation of paxillin-p130-PI3K-AKT signaling axis by Src and PTPRT impacts colon tumorigenesis. Zhao Y, et al. Oncotarget, 2017 Jul 25. PMID 27447856, Free PMC Article
    3. The Functional Variant in the 3'UTR of PTPRT with the Risk of Esophageal Squamous Cell Carcinoma in a Chinese Population. Yao Y, et al. Cell Physiol Biochem, 2015. PMID 25967969
    4. Tumor-derived extracellular mutations of PTPRT /PTPrho are defective in cell adhesion. Yu J, et al. Mol Cancer Res, 2008 Jul. PMID 18644975, Free PMC Article
    5. PTPRT regulates the interaction of Syntaxin-binding protein 1 with Syntaxin 1 through dephosphorylation of specific tyrosine residue. Lim SH, et al. Biochem Biophys Res Commun, 2013 Sep 13. PMID 23962429

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PTPRT could regulate the interaction of Syntaxin-binding protein 1 with Syntaxin 1, and as a result, the synaptic vesicle fusion appears to be controlled through dephosphorylation of Syntaxin-binding protein 1
      Title: PTPRT regulates the interaction of Syntaxin-binding protein 1 with Syntaxin 1 through dephosphorylation of specific tyrosine residue.
    2. BCR is a novel substrate of PTPRT .
      Title: Regulation of dendritic arborization by BCR Rac1 GTPase-activating protein, a substrate of PTPRT.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables STAT family protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables alpha-actinin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables alpha-catenin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cadherin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables delta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables gamma-catenin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thiolester hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane receptor protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to interleukin-6 ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of receptor signaling pathway via STAT ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidyl-tyrosine dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of synapse organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of synapse organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    receptor-type tyrosine-protein phosphatase T
    NP_001102073.2
    NP_001388938.1
    XP_038961463.1
    XP_038961464.1
    XP_038961465.1
    XP_038961467.1
    XP_038961468.1
    XP_063140269.1
    XP_063140270.1
    XP_063140271.1
    XP_063140272.1
    XP_063140273.1
    XP_063140274.1
    XP_063140275.1
    XP_063140276.1
    XP_063140277.1
    XP_063140278.1
    XP_063140279.1
    XP_063140280.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108603.3 → NP_001102073.2  receptor-type tyrosine-protein phosphatase T isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6JX03

    2. NM_001402009.2 → NP_001388938.1  receptor-type tyrosine-protein phosphatase T isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6JX03

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      170608993..171707692 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039105540.2 → XP_038961468.1  receptor-type tyrosine-protein phosphatase T isoform X16

      UniProtKB/TrEMBL
      A6JX03
      Related
      ENSRNOP00000109490.1, ENSRNOT00000163556.1
      Conserved Domains (7) summary
      smart00137
      Location:36 → 193
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      cd00063
      Location:394 → 484
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14630
      Location:904 → 1140
      R-PTPc-T-1; catalytic domain of receptor-type tyrosine-protein phosphatase T, repeat 1
      cd14634
      Location:1225 → 1430
      R-PTPc-T-2; PTP domain of receptor-type tyrosine-protein phosphatase T, repeat 2
      pfam00041
      Location:506 → 581
      fn3; Fibronectin type III domain
      pfam18861
      Location:674 → 776
      PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J
      cl11960
      Location:200 → 285
      Ig; Immunoglobulin domain

    2. XM_039105536.2 → XP_038961464.1  receptor-type tyrosine-protein phosphatase T isoform X12

      UniProtKB/TrEMBL
      A0A8I6AFL3, A6JX03
      Related
      ENSRNOP00000091531.1, ENSRNOT00000102150.2
      Conserved Domains (7) summary
      smart00137
      Location:36 → 193
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      cd00063
      Location:394 → 484
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14630
      Location:904 → 1160
      R-PTPc-T-1; catalytic domain of receptor-type tyrosine-protein phosphatase T, repeat 1
      cd14634
      Location:1245 → 1450
      R-PTPc-T-2; PTP domain of receptor-type tyrosine-protein phosphatase T, repeat 2
      pfam00041
      Location:506 → 581
      fn3; Fibronectin type III domain
      pfam18861
      Location:674 → 776
      PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J
      cl11960
      Location:200 → 285
      Ig; Immunoglobulin domain

    3. XM_039105539.2 → XP_038961467.1  receptor-type tyrosine-protein phosphatase T isoform X15

      UniProtKB/TrEMBL
      A6JX03
      Conserved Domains (7) summary
      smart00137
      Location:36 → 193
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      cd00063
      Location:394 → 484
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14630
      Location:913 → 1149
      R-PTPc-T-1; catalytic domain of receptor-type tyrosine-protein phosphatase T, repeat 1
      cd14634
      Location:1234 → 1439
      R-PTPc-T-2; PTP domain of receptor-type tyrosine-protein phosphatase T, repeat 2
      pfam00041
      Location:506 → 581
      fn3; Fibronectin type III domain
      pfam18861
      Location:674 → 776
      PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J
      cl11960
      Location:200 → 285
      Ig; Immunoglobulin domain

    4. XM_063284208.1 → XP_063140278.1  receptor-type tyrosine-protein phosphatase T isoform X11

      UniProtKB/TrEMBL
      A6JX03

    5. XM_063284207.1 → XP_063140277.1  receptor-type tyrosine-protein phosphatase T isoform X9

      UniProtKB/TrEMBL
      A0A8I5ZW41, A6JX03
      Related
      ENSRNOP00000083869.1, ENSRNOT00000102159.2

    6. XM_063284205.1 → XP_063140275.1  receptor-type tyrosine-protein phosphatase T isoform X7

      UniProtKB/TrEMBL
      A6JX03

    7. XM_063284209.1 → XP_063140279.1  receptor-type tyrosine-protein phosphatase T isoform X14

      UniProtKB/TrEMBL
      A6JX03

    8. XM_039105537.2 → XP_038961465.1  receptor-type tyrosine-protein phosphatase T isoform X13

      UniProtKB/TrEMBL
      A6JX03, F1LXJ9
      Conserved Domains (6) summary
      smart00137
      Location:36 → 193
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      cd00063
      Location:394 → 484
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14630
      Location:923 → 1159
      R-PTPc-T-1; catalytic domain of receptor-type tyrosine-protein phosphatase T, repeat 1
      cd14634
      Location:1244 → 1449
      R-PTPc-T-2; PTP domain of receptor-type tyrosine-protein phosphatase T, repeat 2
      pfam00041
      Location:506 → 581
      fn3; Fibronectin type III domain
      cl11960
      Location:200 → 285
      Ig; Immunoglobulin domain

    9. XM_063284204.1 → XP_063140274.1  receptor-type tyrosine-protein phosphatase T isoform X6

      UniProtKB/TrEMBL
      A6JX03

    10. XM_063284203.1 → XP_063140273.1  receptor-type tyrosine-protein phosphatase T isoform X5

      UniProtKB/TrEMBL
      A6JX03

    11. XM_063284201.1 → XP_063140271.1  receptor-type tyrosine-protein phosphatase T isoform X3

      UniProtKB/TrEMBL
      A6JX03

    12. XM_039105535.2 → XP_038961463.1  receptor-type tyrosine-protein phosphatase T isoform X10

      UniProtKB/TrEMBL
      A6JX03
      Related
      ENSRNOP00000041324.5, ENSRNOT00000044466.6
      Conserved Domains (6) summary
      smart00137
      Location:36 → 193
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      cd00063
      Location:394 → 484
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14630
      Location:933 → 1169
      R-PTPc-T-1; catalytic domain of receptor-type tyrosine-protein phosphatase T, repeat 1
      cd14634
      Location:1254 → 1459
      R-PTPc-T-2; PTP domain of receptor-type tyrosine-protein phosphatase T, repeat 2
      pfam00041
      Location:506 → 581
      fn3; Fibronectin type III domain
      cl11960
      Location:200 → 285
      Ig; Immunoglobulin domain

    13. XM_063284202.1 → XP_063140272.1  receptor-type tyrosine-protein phosphatase T isoform X4

      UniProtKB/TrEMBL
      A6JX03
      Related
      ENSRNOP00000111622.1, ENSRNOT00000141984.1

    14. XM_063284200.1 → XP_063140270.1  receptor-type tyrosine-protein phosphatase T isoform X2

      UniProtKB/TrEMBL
      A6JX03

    15. XM_063284206.1 → XP_063140276.1  receptor-type tyrosine-protein phosphatase T isoform X8

      UniProtKB/TrEMBL
      A6JX03

    16. XM_063284199.1 → XP_063140269.1  receptor-type tyrosine-protein phosphatase T isoform X1

      UniProtKB/TrEMBL
      A6JX03

    17. XM_063284210.1 → XP_063140280.1  receptor-type tyrosine-protein phosphatase T isoform X17

    Nucleotide Protein Strain
    Heading Accession and Version

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