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    Pabpc2 poly(A) binding protein, cytoplasmic 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291615, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pabpc2provided by RGD
    Official Full Name
    poly(A) binding protein, cytoplasmic 2provided by RGD
    Primary source
    RGD:1310759
    See related
    AllianceGenome:RGD:1310759
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable mRNA 3'-UTR binding activity; poly(A) binding activity; and poly(U) RNA binding activity. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasmic stress granule; cytosol; and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    mouse all
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    Genomic context

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    See Pabpc2 in Genome Data Viewer
    Location:
    18p11
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (31905327..31907595)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (31654218..31656486)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (32964763..32967031)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 26 Neighboring gene uncharacterized LOC100911367 Neighboring gene nuclear receptor subfamily 3, group C, member 1 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene Yip1 domain family, member 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The mouse gene encoding the testis-specific isoform of Poly(A) binding protein (Pabp2) is an expressed retroposon: intimations that gene expression in spermatogenic cells facilitates the creation of new genes. Kleene KC, et al. J Mol Evol, 1998 Sep. PMID 9732454
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pabpc2 is a functional retrogene in mouse testis.
      Title: The mouse gene encoding the testis-specific isoform of Poly(A) binding protein (Pabp2) is an expressed retroposon: intimations that gene expression in spermatogenic cells facilitates the creation of new genes.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(A) binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(U) RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    poly(A) binding protein, cytoplasmic 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106151.2 → NP_001099621.1  poly(A) binding protein, cytoplasmic 2

      See identical proteins and their annotated locations for NP_001099621.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A6J3I1, D4A233
      Conserved Domains (6) summary
      TIGR01628
      Location:11 → 609
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12378
      Location:12 → 91
      RRM1_I_PABPs; RNA recognition motif 1 in type I polyadenylate-binding proteins
      cd12379
      Location:97 → 171
      RRM2_I_PABPs; RNA recognition motif 2 found in type I polyadenylate-binding proteins
      cd12380
      Location:190 → 269
      RRM3_I_PABPs; RNA recognition motif 3 found in type I polyadenylate-binding proteins
      cd12381
      Location:293 → 370
      RRM4_I_PABPs; RNA recognition motif 4 in type I polyadenylate-binding proteins
      pfam00658
      Location:542 → 608
      PABP; Poly-adenylate binding protein, unique domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      31905327..31907595
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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