Sh3rf2 SH3 domain containing ring finger 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sh3rf2provided by RGD
Official Full Name: SH3 domain containing ring finger 2provided by RGD
Primary source: RGD:1308415
See related: EnsemblRapid:ENSRNOG00000018780 AllianceGenome:RGD:1308415
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Posh2; Ppp1r39
Summary: Predicted to enable protein phosphatase 1 binding activity and ubiquitin protein ligase activity. Involved in negative regulation of JNK cascade; negative regulation of apoptotic process; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in nucleus. Predicted to be active in nucleoplasm. Orthologous to human SH3RF2 (SH3 domain containing ring finger 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 150.8), Muscle (RPKM 62.0) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18p11

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (34296753..34397880)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (34045715..34148342)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (36371041..36471020)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

a model in which Sh3rf2 promotes proteasomal degradation of pro-apoptotic POSH in healthy cells and in which apoptotic stimuli lead to rapid loss of Sh3rf2 expression, and consequently to stabilization of POSH and JNK activation and cell death
Title: Sh3rf2/POSHER protein promotes cell survival by ring-mediated proteasomal degradation of the c-Jun N-terminal kinase scaffold POSH (Plenty of SH3s) protein.
These results indicate that POSH2 may regulate JNK activation and consequent apoptosis under conditions of increased expression.
Title: Identification of POSH2, a novel homologue of the c-Jun N-terminal kinase scaffold protein POSH.

Submit: New GeneRIF Correction

General gene information

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Markers

D18Mit114 (e-PCR), detects polymorphism
- UniSTS:128136

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatase binding	ISO Inferred from Sequence Orthology more info
enables phosphatase binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase 1 binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase 1 binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase 1 binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein phosphatase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in negative regulation of JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JNK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JNK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein autoubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein autoubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase SH3RF2

Names: POSH-eliminating RING protein; RING finger protein 158; RING-type E3 ubiquitin transferase SH3RF2; SH3 domain-containing RING finger protein 2; protein phosphatase 1 regulatory subunit 39; putative E3 ubiquitin-protein ligase SH3RF2

NP_001029359.1

EC 2.3.2.27

XP_038952781.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001034187.2 → NP_001029359.1 E3 ubiquitin-protein ligase SH3RF2

See identical proteins and their annotated locations for NP_001029359.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000018

UniProtKB/Swiss-Prot

Q498M5

UniProtKB/TrEMBL

A0A8I6AJG7, A6J3J4

Conserved Domains (4) summary

cd11784
Location:387 → 441

SH3_SH3RF2_3; Third Src Homology 3 domain of SH3 domain containing ring finger 2

cd11929
Location:128 → 181

SH3_SH3RF2_1; First Src Homology 3 domain of SH3 domain containing ring finger 2

cd11932
Location:191 → 247

SH3_SH3RF2_2; Second Src Homology 3 domain of SH3 domain containing ring finger 2

cd16749
Location:11 → 55

RING-HC_SH3RF2; RING finger, HC subclass, found in SH3 domain-containing RING finger protein 2 (SH3RF2) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086036.1 Reference GRCr8

Range

34296753..34397880

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039096853.2 → XP_038952781.1 E3 ubiquitin-protein ligase SH3RF2 isoform X1

UniProtKB/Swiss-Prot

Q498M5

UniProtKB/TrEMBL

A0A8I6AJG7, A6J3J4

Related

ENSRNOP00000025409.4, ENSRNOT00000025408.8

Conserved Domains (4) summary

cd11784
Location:387 → 441

SH3_SH3RF2_3; Third Src Homology 3 domain of SH3 domain containing ring finger 2

cd11929
Location:128 → 181

SH3_SH3RF2_1; First Src Homology 3 domain of SH3 domain containing ring finger 2

cd11932
Location:191 → 247

SH3_SH3RF2_2; Second Src Homology 3 domain of SH3 domain containing ring finger 2

cd16749
Location:11 → 55

RING-HC_SH3RF2; RING finger, HC subclass, found in SH3 domain-containing RING finger protein 2 (SH3RF2) and similar proteins