Kctd21 potassium channel tetramerization domain containing 21 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kctd21provided by RGD
Official Full Name: potassium channel tetramerization domain containing 21provided by RGD
Primary source: RGD:1559529
See related: EnsemblRapid:ENSRNOG00000024793 AllianceGenome:RGD:1559529
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1559529
Summary: Predicted to enable cullin family protein binding activity; histone deacetylase binding activity; and identical protein binding activity. Predicted to be involved in negative regulation of smoothened signaling pathway and ubiquitin-dependent protein catabolic process. Orthologous to human KCTD21 (potassium channel tetramerization domain containing 21). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 37.4), Kidney (RPKM 27.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q32

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (161061318..161081002)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (151650074..151669775)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (162307746..162325284)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cullin family protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables cullin family protein binding	ISO Inferred from Sequence Orthology more info
enables histone deacetylase binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone deacetylase binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: BTB/POZ domain-containing protein KCTD21

Names: potassium channel tetramerisation domain containing 21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109151.1 → NP_001102621.1 BTB/POZ domain-containing protein KCTD21

See identical proteins and their annotated locations for NP_001102621.1

Status: PROVISIONAL

Source sequence(s)

CH473956

UniProtKB/TrEMBL

A6I683, D4ADH5

Conserved Domains (1) summary

cd18395
Location:3 → 100

BTB_POZ_KCTD21; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 21 (KCTD21)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

161061318..161081002

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006229781.5 → XP_006229843.1 BTB/POZ domain-containing protein KCTD21 isoform X1

See identical proteins and their annotated locations for XP_006229843.1

UniProtKB/TrEMBL

A6I683, D4ADH5

Related

ENSRNOP00000111137.1, ENSRNOT00000158194.1

Conserved Domains (1) summary

cd18395
Location:3 → 100

BTB_POZ_KCTD21; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 21 (KCTD21)
XM_039087670.2 → XP_038943598.1 BTB/POZ domain-containing protein KCTD21 isoform X1

UniProtKB/TrEMBL

A6I683, D4ADH5

Related

ENSRNOP00000101211.1, ENSRNOT00000131315.1

Conserved Domains (1) summary

cd18395
Location:3 → 100

BTB_POZ_KCTD21; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 21 (KCTD21)