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    Sp5 Sp5 transcription factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296510, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sp5provided by RGD
    Official Full Name
    Sp5 transcription factorprovided by RGD
    Primary source
    RGD:1308499
    See related
    EnsemblRapid:ENSRNOG00000054086 AllianceGenome:RGD:1308499
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within bone morphogenesis; cellular response to organic cyclic compound; and post-anal tail morphogenesis. Predicted to be located in nucleus. Orthologous to human SP5 (Sp5 transcription factor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 7.0), Brain (RPKM 2.7) and 5 other tissues See more
    Orthologs
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    Genomic context

    See Sp5 in Genome Data Viewer
    Location:
    3q22
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (75682677..75685479)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (55274931..55277733)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (56766475..56769277)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene myosin IIIB Neighboring gene uncharacterized LOC134486378 Neighboring gene uncharacterized LOC134486379 Neighboring gene uncharacterized LOC120101561 Neighboring gene uncharacterized LOC134486380 Neighboring gene glutamate-rich 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General protein information

    Preferred Names
    transcription factor Sp5
    Names
    trans-acting transcription factor 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106552.1NP_001100022.1  transcription factor Sp5

      See identical proteins and their annotated locations for NP_001100022.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473949
      UniProtKB/TrEMBL
      A0A0G2JUC1, A6HM29
      Related
      ENSRNOP00000069042.1, ENSRNOT00000078819.3
      Conserved Domains (5) summary
      COG5048
      Location:311384
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:301320
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:342365
      zf-H2C2_2; Zinc-finger double domain
      cd22541
      Location:106297
      SP5_N; N-terminal domain of transcription factor Specificity Protein (SP) 5
      cl41773
      Location:3147
      SP1-4_N; N-terminal domain of transcription factor Specificity Proteins (SP) 1-4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      75682677..75685479
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)