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    Kcng4 potassium voltage-gated channel modifier subfamily G member 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307900, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kcng4provided by RGD
    Official Full Name
    potassium voltage-gated channel modifier subfamily G member 4provided by RGD
    Primary source
    RGD:1308553
    See related
    EnsemblRapid:ENSRNOG00000015746 AllianceGenome:RGD:1308553
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable potassium channel regulator activity and transmembrane transporter binding activity. Predicted to be involved in action potential; potassium ion transmembrane transport; and regulation of potassium ion transmembrane transport. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in membrane. Orthologous to human KCNG4 (potassium voltage-gated channel modifier subfamily G member 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 32.1) and Testes (RPKM 4.4) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kcng4 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (64585252..64598025, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (47677307..47689410, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (52270907..52283317, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene TATA-box binding protein associated factor, RNA polymerase 1 subunit C Neighboring gene adenosine deaminase domain containing 2 Neighboring gene WAP four-disulfide core domain 1 Neighboring gene transfer RNA alanine (anticodon AGC) 94

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutation of histidine 105 in the T1 domain of the potassium channel Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4. Mederos Y Schnitzler M, et al. J Biol Chem, 2009 Feb 13. PMID 19074135
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables potassium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of potassium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    potassium voltage-gated channel subfamily G member 4
    Names
    potassium channel, voltage gated modifier subfamily G, member 4
    potassium voltage-gated channel, subfamily G, member 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107435.2 → NP_001100905.1  potassium voltage-gated channel subfamily G member 4

      See identical proteins and their annotated locations for NP_001100905.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A6IZK0, D4AD66
      Related
      ENSRNOP00000021271.4, ENSRNOT00000021271.8
      Conserved Domains (4) summary
      smart00225
      Location:60 → 167
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:260 → 463
      Ion_trans; Ion transport protein
      pfam02214
      Location:60 → 159
      BTB_2; BTB/POZ domain
      pfam07885
      Location:397 → 457
      Ion_trans_2; Ion channel

    2. NM_001434515.1 → NP_001421444.1  potassium voltage-gated channel subfamily G member 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A6IZK0, D4AD66

    3. NM_001434516.1 → NP_001421445.1  potassium voltage-gated channel subfamily G member 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A6IZK0, D4AD66

    4. NM_001434517.1 → NP_001421446.1  potassium voltage-gated channel subfamily G member 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A6IZK0, D4AD66

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      64585252..64598025 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063278061.1 → XP_063134131.1  potassium voltage-gated channel subfamily G member 4 isoform X2

    2. XM_006255710.5 → XP_006255772.1  potassium voltage-gated channel subfamily G member 4 isoform X1

      Conserved Domains (4) summary
      smart00225
      Location:60 → 167
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:260 → 463
      Ion_trans; Ion transport protein
      pfam02214
      Location:60 → 159
      BTB_2; BTB/POZ domain
      pfam07885
      Location:397 → 457
      Ion_trans_2; Ion channel

    3. XM_006255711.5 → XP_006255773.1  potassium voltage-gated channel subfamily G member 4 isoform X1

      Conserved Domains (4) summary
      smart00225
      Location:60 → 167
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:260 → 463
      Ion_trans; Ion transport protein
      pfam02214
      Location:60 → 159
      BTB_2; BTB/POZ domain
      pfam07885
      Location:397 → 457
      Ion_trans_2; Ion channel

    4. XM_006255709.5 → XP_006255771.1  potassium voltage-gated channel subfamily G member 4 isoform X1

      Conserved Domains (4) summary
      smart00225
      Location:60 → 167
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:260 → 463
      Ion_trans; Ion transport protein
      pfam02214
      Location:60 → 159
      BTB_2; BTB/POZ domain
      pfam07885
      Location:397 → 457
      Ion_trans_2; Ion channel
    Nucleotide Protein Strain
    Heading Accession and Version

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