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    Tmem220 transmembrane protein 220 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287405, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmem220provided by RGD
    Official Full Name
    transmembrane protein 220provided by RGD
    Primary source
    RGD:1309576
    See related
    EnsemblRapid:ENSRNOG00000003367 AllianceGenome:RGD:1309576
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309576
    Summary
    Orthologous to human TMEM220 (transmembrane protein 220). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 32.4), Lung (RPKM 22.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmem220 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (52218782..52229302)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (51719777..51728792)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (53570980..53579994)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095123 Neighboring gene transmembrane protein 238 like Neighboring gene uncharacterized LOC134480699 Neighboring gene ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent Neighboring gene synthesis of cytochrome C oxidase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    transmembrane protein 220

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305124.1 → NP_001292053.1  transmembrane protein 220 isoform 1

      See identical proteins and their annotated locations for NP_001292053.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HFH0, A6HFH1, D4A2I6
      Related
      ENSRNOP00000004516.5, ENSRNOT00000004516.9
      Conserved Domains (1) summary
      pfam15071
      Location:29 → 118
      TMEM220; Transmembrane family 220, helix

    2. NM_001305125.1 → NP_001292054.1  transmembrane protein 220 isoform 2

      See identical proteins and their annotated locations for NP_001292054.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate exon in its 5' UTR and uses a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform.
      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HFH2, D4A6Z7
      Conserved Domains (1) summary
      pfam15071
      Location:1 → 45
      TMEM220; Transmembrane family 220, helix

    3. NM_001305126.1 → NP_001292055.1  transmembrane protein 220 isoform 2

      See identical proteins and their annotated locations for NP_001292055.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an exon in its 5' UTR and uses a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform.
      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HFH2, D4A6Z7
      Conserved Domains (1) summary
      pfam15071
      Location:1 → 45
      TMEM220; Transmembrane family 220, helix

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      52218782..52229302
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085433.2 → XP_038941361.1  transmembrane protein 220 isoform X1

      UniProtKB/TrEMBL
      A6HFH2, D4A6Z7
      Conserved Domains (1) summary
      pfam15071
      Location:1 → 45
      TMEM220; Transmembrane family 220, helix
    Nucleotide Protein Strain
    Heading Accession and Version

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