Gatd1 glutamine amidotransferase class 1 domain containing 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gatd1provided by RGD
Official Full Name: glutamine amidotransferase class 1 domain containing 1provided by RGD
Primary source: RGD:1304836
See related: EnsemblRapid:ENSRNOG00000045795 AllianceGenome:RGD:1304836
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pddc1; RGD1304836
Summary: Predicted to enable glyoxalase III activity. Predicted to be involved in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione. Predicted to be located in early endosome and extracellular region. Predicted to be active in cytoplasm. Orthologous to human GATD1 (glutamine amidotransferase class 1 domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 185.5), Kidney (RPKM 137.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q41

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (205936189..205942121, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (196504533..196512561, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (214389006..214394451, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables glyoxalase III activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in lactate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: glutamine amidotransferase-like class 1 domain-containing protein 1

Names: Parkinson disease 7 domain containing 1; Parkinson disease 7 domain-containing protein 1; Parkinson disease 7 domain-containing protein 1-like; glutamine amidotransferase like class 1 domain containing 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107563.2 → NP_001101033.1 glutamine amidotransferase-like class 1 domain-containing protein 1

See identical proteins and their annotated locations for NP_001101033.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A6HXV9, A6HXW0

Conserved Domains (2) summary

cd03141
Location:12 → 216

GATase1_Hsp31_like; Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein

COG0693
Location:31 → 204

ThiJ; Putative intracellular protease/amidase [General function prediction only]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

205936189..205942121 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017590251.3 → XP_017445740.2 glutamine amidotransferase-like class 1 domain-containing protein 1 isoform X1

UniProtKB/TrEMBL

D3ZVI9

Related

ENSRNOP00000065958.3, ENSRNOT00000073220.4

Conserved Domains (1) summary

cl00020
Location:37 → 176

GAT_1; Type 1 glutamine amidotransferase (GATase1)-like domain