Tafa5 TAFA chemokine like family member 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tafa5provided by RGD
Official Full Name: TAFA chemokine like family member 5provided by RGD
Primary source: RGD:1562115
See related: EnsemblRapid:ENSRNOG00000049349 AllianceGenome:RGD:1562115
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tafa-5; Fam19a5; RGD1562115
Summary: Enables receptor ligand activity. Acts upstream of or within several processes, including negative regulation of vascular associated smooth muscle cell migration; negative regulation of vascular associated smooth muscle cell proliferation; and negative regulation of vascular wound healing. Located in extracellular space. Orthologous to human TAFA5 (TAFA chemokine like family member 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 158.8), Testes (RPKM 17.8) and 3 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 7q34

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (120493447..120714720)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (118613731..118835016)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (128500009..128728834)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Novel adipokine, FAM19A5, was capable of inhibiting postinjury neointima formation via sphingosine-1-phosphate receptor 2-G12/13-RhoA signaling.
Title: Novel Adipokine, FAM19A5, Inhibits Neointima Formation After Injury Through Sphingosine-1-Phosphate Receptor 2.
we found TAFA5 mRNA to be highly expressed in the hypothalamic paraventricular nucleus (PVN) where it co-localized with vasopressin and oxytocin in magno- and parvocellular neurons.
Title: The putative neuropeptide TAFA5 is expressed in the hypothalamic paraventricular nucleus and is regulated by dehydration.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor binding	ISO Inferred from Sequence Orthology more info
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables receptor ligand activity	IBA Inferred from Biological aspect of Ancestor more info
enables receptor ligand activity	IDA Inferred from Direct Assay more info	PubMed
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell migration	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of vascular wound healing	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of vascular wound healing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: chemokine-like protein TAFA-5

Names: family with sequence similarity 19 (chemokine (C-C motif)-like), member A5; family with sequence similarity 19 member A5, C-C motif chemokine like; protein FAM19A5

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191991.1 → NP_001178920.1 chemokine-like protein TAFA-5 precursor

See identical proteins and their annotated locations for NP_001178920.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

M0R7X9

Conserved Domains (1) summary

pfam12020
Location:42 → 131

TAFA; TAFA family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

120493447..120714720

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039079768.2 → XP_038935696.1 chemokine-like protein TAFA-5 isoform X3

Related

ENSRNOP00000065567.2, ENSRNOT00000074625.4

Conserved Domains (1) summary

pfam12020
Location:42 → 92

TAFA; TAFA family
XM_017595060.3 → XP_017450549.1 chemokine-like protein TAFA-5 isoform X2

UniProtKB/TrEMBL

A6K7G7

Related

ENSRNOP00000102712.1, ENSRNOT00000135490.1

Conserved Domains (1) summary

pfam12020
Location:35 → 124

TAFA; TAFA family
XM_039079767.2 → XP_038935695.1 chemokine-like protein TAFA-5 isoform X1

Conserved Domains (1) summary

pfam12020
Location:35 → 85

TAFA; TAFA family