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    Oscar osteoclast associated Ig-like receptor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292537, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Oscarprovided by RGD
    Official Full Name
    osteoclast associated Ig-like receptorprovided by RGD
    Primary source
    RGD:1559897
    See related
    EnsemblRapid:ENSRNOG00000055716 AllianceGenome:RGD:1559897
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1559897
    Summary
    Predicted to enable collagen receptor activity. Predicted to be involved in immune response-regulating signaling pathway. Predicted to act upstream of or within Fc-gamma receptor signaling pathway; multinuclear osteoclast differentiation; and positive regulation of bone resorption. Predicted to be located in cell surface. Predicted to be active in plasma membrane. Orthologous to human OSCAR (osteoclast associated Ig-like receptor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 8.9), Lung (RPKM 8.4) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Oscar in Genome Data Viewer
    Location:
    1q12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (74521626..74529119)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (65607214..65615395)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (64182174..64188658)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene TCF3 fusion partner Neighboring gene NADH:ubiquinone oxidoreductase subunit A3 Neighboring gene T cell-interacting, activating receptor on myeloid cells 1 like 1 Neighboring gene T cell-interacting, activating receptor on myeloid cells 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A novel member of the leukocyte receptor complex regulates osteoclast differentiation. Kim N, et al. J Exp Med, 2002 Jan 21. PMID 11805147, Free PMC Article
    2. Involvement of FcRgamma in signal transduction of osteoclast-associated receptor (OSCAR). Ishikawa S, et al. Int Immunol, 2004 Jul. PMID 15184345
    3. OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice. Barrow AD, et al. J Clin Invest, 2011 Sep. PMID 21841309, Free PMC Article
    4. Telmisartan Prevents Alveolar Bone Loss by Decreasing the Expression of Osteoclasts Markers in Hypertensive Rats With Periodontal Disease. Brito VGB, et al. Front Pharmacol, 2020. PMID 33364953, Free PMC Article
    5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables collagen receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables collagen receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Fc-gamma receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in collagen-activated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in immune response-regulating signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within multinuclear osteoclast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within osteoclast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of bone resorption ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    osteoclast-associated immunoglobulin-like receptor
    Names
    osteoclast associated receptor
    osteoclast associated, immunoglobulin-like receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001184973.1 → NP_001171902.1  osteoclast-associated immunoglobulin-like receptor precursor

      See identical proteins and their annotated locations for NP_001171902.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474101
      UniProtKB/TrEMBL
      A0A8I5ZN02, A6KS33
      Related
      ENSRNOP00000087390.2, ENSRNOT00000106643.2
      Conserved Domains (1) summary
      cl11960
      Location:36 → 129
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      74521626..74529119
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039103706.2 → XP_038959634.1  osteoclast-associated immunoglobulin-like receptor isoform X2

      Conserved Domains (2) summary
      cd00096
      Location:29 → 33
      Ig; Ig strand A [structural motif]
      cl11960
      Location:28 → 114
      Ig; Immunoglobulin domain

    2. XM_006228020.5 → XP_006228082.1  osteoclast-associated immunoglobulin-like receptor isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZN02, D3ZCA1
      Conserved Domains (1) summary
      cl11960
      Location:30 → 123
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version

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