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    Vwc2l von Willebrand factor C domain containing 2 like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 501160, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Vwc2lprovided by RGD
    Official Full Name
    von Willebrand factor C domain containing 2 likeprovided by RGD
    Primary source
    RGD:1565501
    See related
    EnsemblRapid:ENSRNOG00000027400 AllianceGenome:RGD:1565501
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565501
    Summary
    Predicted to be involved in negative regulation of BMP signaling pathway. Predicted to act upstream of or within positive regulation of neuron differentiation. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in extracellular space. Orthologous to human VWC2L (von Willebrand factor C domain containing 2 like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 39.6) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Vwc2l in Genome Data Viewer
    Location:
    9q33
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (79702396..79897153)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (72252793..72448543)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (77833534..78024670)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene sperm associated antigen 16 Neighboring gene tubulin, beta 4B class IVb, pseudogene 4 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene uncharacterized LOC120094698 Neighboring gene BRCA1 associated RING domain 1 Neighboring gene ATP binding cassette subfamily A member 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A novel neural-specific BMP antagonist, Brorin-like, of the Chordin family. Miwa H, et al. FEBS Lett, 2009 Nov 19. PMID 19852960
    2. High-resolution proteomics unravel architecture and molecular diversity of native AMPA receptor complexes. Schwenk J, et al. Neuron, 2012 May 24. PMID 22632720
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in negative regulation of BMP signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of AMPA glutamate receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of AMPA glutamate receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    von Willebrand factor C domain-containing protein 2-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001413944.1 → NP_001400873.1  von Willebrand factor C domain-containing protein 2-like isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I6AU98
      Related
      ENSRNOP00000096961.1, ENSRNOT00000095991.2

    2. NM_001413945.1 → NP_001400874.1  von Willebrand factor C domain-containing protein 2-like isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      Related
      ENSRNOP00000107695.1, ENSRNOT00000150145.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      79702396..79897153
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017596605.3 → XP_017452094.1  von Willebrand factor C domain-containing protein 2-like isoform X2

      UniProtKB/TrEMBL
      A6KFF7, D4A0X1
      Related
      ENSRNOP00000105902.1, ENSRNOT00000134443.1
      Conserved Domains (1) summary
      cl17735
      Location:69 → 124
      VWC; von Willebrand factor type C domain

    2. XM_039084106.2 → XP_038940034.1  von Willebrand factor C domain-containing protein 2-like isoform X1

      Conserved Domains (1) summary
      cl17735
      Location:116 → 171
      VWC; von Willebrand factor type C domain
    Nucleotide Protein Strain
    Heading Accession and Version

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