Tuba1a tubulin, alpha 1A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tuba1aprovided by RGD
Official Full Name: tubulin, alpha 1Aprovided by RGD
Primary source: RGD:619717
See related: EnsemblRapid:ENSRNOG00000072536 AllianceGenome:RGD:619717
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tuba1
Summary: Enables protein domain specific binding activity. Predicted to be involved in several processes, including learning or memory; microtubule cytoskeleton organization; and nervous system development. Located in membrane raft and myelin sheath. Human ortholog(s) of this gene implicated in lissencephaly; lissencephaly 3; microcephaly; and visual epilepsy. Orthologous to human TUBA1A (tubulin alpha 1a). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 3984.9), Thymus (RPKM 3173.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q36

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (131992151..131996850, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (130113214..130116880, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (140637287..140640953, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

alpha-Tubulin acetylation on lysine 40 controls cardiac glucose uptake.
Title: α-Tubulin acetylation on lysine 40 controls cardiac glucose uptake.
HDAC6-mediated alpha-tubulin acetylation is an important mechanism of acidic pH-dependent autophagy in cardiomyocytes.
Title: Decreased α-tubulin acetylation induced by an acidic environment impairs autophagosome formation and leads to rat cardiomyocyte injury.
These results agree with the hypothesis that the acetylation of alpha-tubulin by ATAT1 regulates the intracellular transport of secretory granules in corticotrophs.
Title: Adrenalectomy facilitates ATAT1 expression and α-tubulin acetylation in ACTH-producing corticotrophs.
We demonstrated that MeCP2 may negatively control the acetylation of alpha-tubulin through HDAC6 in cardiac fibroblast proliferation and fibrosis
Title: Epigenetic factors MeCP2 and HDAC6 control α-tubulin acetylation in cardiac fibroblast proliferation and fibrosis.
Tubulin tail sequences and post-translational modifications regulate closure of mitochondrial voltage-dependent anion channel, VDAC.
Title: Tubulin tail sequences and post-translational modifications regulate closure of mitochondrial voltage-dependent anion channel (VDAC).
TTL has specifically evolved to recognize and modify tubulin.
Title: Structural basis of tubulin tyrosination by tubulin tyrosine ligase.
This finding reveals the importance of MEC-17 and alpha-tubulin acetylation in cortical development.
Title: MEC-17 deficiency leads to reduced α-tubulin acetylation and impaired migration of cortical neurons.
VDAC phosphorylation is an important determinant of its interaction with dimeric tubulin.
Title: Phosphorylation of voltage-dependent anion channel by serine/threonine kinases governs its interaction with tubulin.
These results show that acetylation of alpha-tubulin is modulated in an activity-dependent manner in the rat hippocampus.
Title: Activity-dependent acetylation of alpha tubulin in the hippocampus.
Alpha2B-adrenergic receptor interaction with tubulin controls its transport from the endoplasmic reticulum to the cell surface
Title: Alpha2B-adrenergic receptor interaction with tubulin controls its transport from the endoplasmic reticulum to the cell surface.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D22S1042 (e-PCR)
- UniSTS:67652

D5Arb10 (e-PCR)
- UniSTS:240478

RH78682 (e-PCR)
- UniSTS:80224

PMC86714P2 (e-PCR)
- UniSTS:273550

PMC154451P2 (e-PCR)
- UniSTS:271312

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IDA Inferred from Direct Assay more info	PubMed
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	TAS Traceable Author Statement more info	PubMed
enables structural constituent of cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of cytoskeleton	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in adult behavior	ISO Inferred from Sequence Orthology more info
involved_in adult locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in cellular response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in centrosome cycle	ISO Inferred from Sequence Orthology more info
involved_in cerebellar cortex morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cerebral cortex development	ISO Inferred from Sequence Orthology more info
involved_in cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in dentate gyrus development	ISO Inferred from Sequence Orthology more info
involved_in flagellated sperm motility	ISO Inferred from Sequence Orthology more info
involved_in forebrain morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in gene expression	ISO Inferred from Sequence Orthology more info
involved_in glial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in hippocampus development	ISO Inferred from Sequence Orthology more info
involved_in homeostasis of number of cells within a tissue	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transport	ISO Inferred from Sequence Orthology more info
involved_in locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in locomotory exploration behavior	ISO Inferred from Sequence Orthology more info
involved_in memory	ISO Inferred from Sequence Orthology more info
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in microtubule polymerization	ISO Inferred from Sequence Orthology more info
involved_in microtubule-based process	IEA Inferred from Electronic Annotation more info
involved_in microtubule-based process	TAS Traceable Author Statement more info	PubMed
involved_in mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in motor behavior	ISO Inferred from Sequence Orthology more info
involved_in neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in neuron migration	ISO Inferred from Sequence Orthology more info
involved_in neuron projection arborization	ISO Inferred from Sequence Orthology more info
involved_in organelle transport along microtubule	ISO Inferred from Sequence Orthology more info
involved_in pyramidal neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of synapse organization	ISO Inferred from Sequence Orthology more info
involved_in response to L-glutamate	ISO Inferred from Sequence Orthology more info
involved_in response to mechanical stimulus	ISO Inferred from Sequence Orthology more info
involved_in response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
involved_in smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in startle response	ISO Inferred from Sequence Orthology more info
involved_in synapse organization	ISO Inferred from Sequence Orthology more info
involved_in visual learning	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axonemal microtubule	ISO Inferred from Sequence Orthology more info
is_active_in condensed chromosome	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic microtubule	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic ribonucleoprotein granule	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in microtubule	ISO Inferred from Sequence Orthology more info
located_in microtubule	TAS Traceable Author Statement more info	PubMed
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in motile cilium	IEA Inferred from Electronic Annotation more info
located_in myelin sheath	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuromuscular junction	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in recycling endosome	ISO Inferred from Sequence Orthology more info
is_active_in sperm flagellum	ISO Inferred from Sequence Orthology more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tubulin alpha-1A chain

Names: alpha-tubulin 1; tubulin alpha-1 chain; tubulin, alpha 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022298.1 → NP_071634.1 tubulin alpha-1A chain

See identical proteins and their annotated locations for NP_071634.1

Status: PROVISIONAL

Source sequence(s)

V01227

UniProtKB/Swiss-Prot

P68370, Q6P6G6

UniProtKB/TrEMBL

A0A8I6ALV8, A6KCD0

Related

ENSRNOP00000104758.1, ENSRNOT00000147922.1

Conserved Domains (1) summary

PTZ00335
Location:1 → 440

PTZ00335; tubulin alpha chain; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

131992151..131996850 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063264207.1 → XP_063120277.1 tubulin alpha-1A chain isoform X1

UniProtKB/Swiss-Prot

P68370, Q6P6G6

UniProtKB/TrEMBL

A0A8I6ALV8, A6KCD0
XM_063264206.1 → XP_063120276.1 tubulin alpha-1A chain isoform X1

UniProtKB/Swiss-Prot

P68370, Q6P6G6

UniProtKB/TrEMBL

A0A8I6ALV8, A6KCD0
XM_063264205.1 → XP_063120275.1 tubulin alpha-1A chain isoform X1

UniProtKB/Swiss-Prot

P68370, Q6P6G6

UniProtKB/TrEMBL

A0A8I6ALV8, A6KCD0