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    Grm5 glutamate metabotropic receptor 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24418, updated on 9-Dec-2024

    Summary

    Official Symbol
    Grm5provided by RGD
    Official Full Name
    glutamate metabotropic receptor 5provided by RGD
    Primary source
    RGD:2746
    See related
    EnsemblRapid:ENSRNOG00000016429 AllianceGenome:RGD:2746
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    mGluR5; mGlur5
    Summary
    Enables several functions, including A2A adenosine receptor binding activity; protein tyrosine kinase activator activity; and protein tyrosine kinase binding activity. Involved in several processes, including G protein-coupled glutamate receptor signaling pathway; positive regulation of long-term neuronal synaptic plasticity; and regulation of signal transduction. Located in astrocyte projection; dendrite; and neuronal cell body. Is active in glutamatergic synapse and postsynaptic membrane. Orthologous to human GRM5 (glutamate metabotropic receptor 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 246.3) See more
    Orthologs
    NEW
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    Genomic context

    See Grm5 in Genome Data Viewer
    Location:
    1q32
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (150722711..151297585)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (141310069..141884980)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (151207846..151785038)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene U7 small nuclear RNA Neighboring gene U7 small nuclear RNA Neighboring gene tyrosinase Neighboring gene splicing factor 3A subunit 1, pseudogene 1 Neighboring gene eukaryotic translation initiation factor 5, pseudogene 5 Neighboring gene uncharacterized LOC102554680 Neighboring gene cathepsin C

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables A2A adenosine receptor binding PubMed 
    enables G protein-coupled receptor activity  
    enables G protein-coupled receptor activity  
    enables G protein-coupled receptor activity  
    enables G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential  
    enables PDZ domain binding PubMed 
    enables PLC activating G protein-coupled glutamate receptor activity PubMed 
    enables adenylate cyclase inhibiting G protein-coupled glutamate receptor activity  
    enables calmodulin binding PubMed 
    enables glutamate receptor activity  
    enables glutamate receptor activity PubMed 
    enables glutamate receptor activity  
    enables glutamate receptor activity  
    enables identical protein binding  
    enables identical protein binding  
    enables neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration  
    enables protein binding PubMed 
    enables protein tyrosine kinase activator activity  
    enables protein tyrosine kinase activator activity PubMed 
    enables protein tyrosine kinase activator activity  
    enables protein tyrosine kinase binding PubMed 
    Items 1 - 25 of 36
    Process Evidence Code Pubs
    involved_in G protein-coupled glutamate receptor signaling pathway  
    involved_in G protein-coupled glutamate receptor signaling pathway PubMed 
    involved_in G protein-coupled glutamate receptor signaling pathway  
    involved_in G protein-coupled glutamate receptor signaling pathway  
    involved_in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway  
    involved_in cellular response to amyloid-beta  
    involved_in cellular response to amyloid-beta  
    involved_in chemical synaptic transmission  
    involved_in chemical synaptic transmission PubMed 
    involved_in cognition  
    involved_in desensitization of G protein-coupled receptor signaling pathway PubMed 
    involved_in learning  
    acts_upstream_of_or_within learning  
    involved_in learning or memory  
    involved_in locomotory behavior  
    acts_upstream_of_or_within locomotory behavior  
    involved_in modulation of chemical synaptic transmission  
    involved_in phosphatidylinositol-mediated signaling PubMed 
    involved_in phospholipase C-activating G protein-coupled glutamate receptor signaling pathway  
    involved_in phospholipase C-activating G protein-coupled glutamate receptor signaling pathway  
    involved_in phospholipase C-activating G protein-coupled glutamate receptor signaling pathway PubMed 
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway PubMed 
    involved_in positive regulation of MAPK cascade PubMed 
    involved_in positive regulation of calcium-mediated signaling  
    involved_in positive regulation of calcium-mediated signaling  
    involved_in positive regulation of long-term neuronal synaptic plasticity PubMed 
    involved_in protein phosphorylation PubMed 
    involved_in regulation of DNA-templated transcription PubMed 
    involved_in regulation of long-term neuronal synaptic plasticity  
    acts_upstream_of_or_within regulation of long-term neuronal synaptic plasticity  
    involved_in regulation of postsynaptic cytosolic calcium ion concentration  
    involved_in regulation of postsynaptic membrane potential  
    involved_in regulation of synaptic transmission, glutamatergic  
    involved_in synapse organization  
    involved_in synapse organization  
    involved_in trans-synaptic signaling by endocannabinoid, modulating synaptic transmission  
    Items 1 - 25 of 36
    Items 1 - 20 of 21
    Component Evidence Code Pubs
    located_in Schaffer collateral - CA1 synapse  
    is_active_in Schaffer collateral - CA1 synapse  
    located_in astrocyte projection PubMed 
    located_in cytoplasm  
    located_in cytoplasm  
    located_in dendrite  
    is_active_in dendrite  
    located_in dendritic shaft PubMed 
    located_in dendritic spine PubMed 
    is_active_in glutamatergic synapse PubMed 
    located_in neuron projection PubMed 
    located_in neuron projection  
    located_in neuronal cell body PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    is_active_in postsynaptic density membrane  
    is_active_in postsynaptic membrane PubMed 
    located_in postsynaptic membrane PubMed 
    located_in synapse  
    Items 1 - 20 of 21

    General protein information

    Preferred Names
    metabotropic glutamate receptor 5
    Names
    glutamate receptor, metabotropic 5
    metabotropic glutamate receptor (mGluR5)
    metabotropic glutamate receptor 5b

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017012.2NP_058708.1  metabotropic glutamate receptor 5 precursor

      See identical proteins and their annotated locations for NP_058708.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A0H2UHW6, A6I5Y9
      Related
      ENSRNOP00000040016.3, ENSRNOT00000050639.4
      Conserved Domains (5) summary
      cd06374
      Location:26496
      PBP1_mGluR_groupI; Ligand binding domain of the group I metabotropic glutamate receptor
      pfam00003
      Location:590823
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
      pfam01094
      Location:67471
      ANF_receptor; Receptor family ligand binding region
      pfam07562
      Location:507556
      NCD3G; Nine Cysteines Domain of family 3 GPCR
      pfam10606
      Location:11211171
      GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      150722711..151297585
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039096032.2XP_038951960.1  metabotropic glutamate receptor 5 isoform X1

      UniProtKB/Swiss-Prot
      P31424
      UniProtKB/TrEMBL
      A0A0H2UHN1, B2CZC8
      Conserved Domains (5) summary
      pfam05109
      Location:10131171
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cd15450
      Location:577826
      7tmC_mGluR5; metabotropic glutamate receptor 5 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors
      cd06374
      Location:26496
      PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor
      pfam07562
      Location:507557
      NCD3G; Nine Cysteines Domain of family 3 GPCR
      pfam10606
      Location:11541203
      GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor
    2. XM_017588778.3XP_017444267.1  metabotropic glutamate receptor 5 isoform X1

      UniProtKB/Swiss-Prot
      P31424
      UniProtKB/TrEMBL
      A0A0H2UHN1, B2CZC8
      Conserved Domains (5) summary
      pfam05109
      Location:10131171
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cd15450
      Location:577826
      7tmC_mGluR5; metabotropic glutamate receptor 5 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors
      cd06374
      Location:26496
      PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor
      pfam07562
      Location:507557
      NCD3G; Nine Cysteines Domain of family 3 GPCR
      pfam10606
      Location:11541203
      GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor
    3. XM_006229659.5XP_006229721.1  metabotropic glutamate receptor 5 isoform X1

      See identical proteins and their annotated locations for XP_006229721.1

      UniProtKB/Swiss-Prot
      P31424
      UniProtKB/TrEMBL
      A0A0H2UHN1, B2CZC8
      Related
      ENSRNOP00000106840.1, ENSRNOT00000157575.1
      Conserved Domains (5) summary
      pfam05109
      Location:10131171
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cd15450
      Location:577826
      7tmC_mGluR5; metabotropic glutamate receptor 5 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors
      cd06374
      Location:26496
      PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor
      pfam07562
      Location:507557
      NCD3G; Nine Cysteines Domain of family 3 GPCR
      pfam10606
      Location:11541203
      GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor
    4. XM_017588781.3XP_017444270.1  metabotropic glutamate receptor 5 isoform X2

      UniProtKB/TrEMBL
      A0A0H2UHW6, A6I5Y9
    5. XM_063280722.1XP_063136792.1  metabotropic glutamate receptor 5 isoform X2

      UniProtKB/TrEMBL
      A0A0H2UHW6, A6I5Y9
    6. XM_017588780.3XP_017444269.1  metabotropic glutamate receptor 5 isoform X1

      UniProtKB/Swiss-Prot
      P31424
      UniProtKB/TrEMBL
      A0A0H2UHN1, B2CZC8
      Related
      ENSRNOP00000022059.5, ENSRNOT00000022060.7
      Conserved Domains (5) summary
      pfam05109
      Location:10131171
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cd15450
      Location:577826
      7tmC_mGluR5; metabotropic glutamate receptor 5 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors
      cd06374
      Location:26496
      PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor
      pfam07562
      Location:507557
      NCD3G; Nine Cysteines Domain of family 3 GPCR
      pfam10606
      Location:11541203
      GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor
    7. XM_063280720.1XP_063136790.1  metabotropic glutamate receptor 5 isoform X2

      UniProtKB/TrEMBL
      A0A0H2UHW6, A6I5Y9
    8. XM_017588779.3XP_017444268.1  metabotropic glutamate receptor 5 isoform X1

      UniProtKB/Swiss-Prot
      P31424
      UniProtKB/TrEMBL
      A0A0H2UHN1, B2CZC8
      Conserved Domains (5) summary
      pfam05109
      Location:10131171
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cd15450
      Location:577826
      7tmC_mGluR5; metabotropic glutamate receptor 5 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors
      cd06374
      Location:26496
      PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor
      pfam07562
      Location:507557
      NCD3G; Nine Cysteines Domain of family 3 GPCR
      pfam10606
      Location:11541203
      GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor
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