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    C2cd6 C2 calcium dependent domain containing 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 501147, updated on 9-Dec-2024

    Summary

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    Symbol
    C2cd6provided by RGD
    Full Name
    C2 calcium dependent domain containing 6provided by RGD
    Primary source
    RGD:1565450
    See related
    EnsemblRapid:ENSRNOG00000012637 AllianceGenome:RGD:1565450
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Als2cr11
    Summary
    Predicted to be involved in flagellated sperm motility; sperm capacitation; and vesicle-mediated transport to the plasma membrane. Predicted to be located in sperm principal piece. Predicted to be part of CatSper complex. Human ortholog(s) of this gene implicated in spermatogenic failure 68. Orthologous to human C2CD6 (C2 calcium dependent domain containing 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 588.3) See more
    Orthologs
    human mouse all
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    Genomic context

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    See C2cd6 in Genome Data Viewer
    Location:
    9q31
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (67929069..68024993, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (60434926..60530842, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (65817039..65879564, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094796 Neighboring gene trafficking kinesin protein 2 Neighboring gene transfer RNA valine (anticodon AAC) 15 Neighboring gene STE20 related adaptor beta Neighboring gene uncharacterized LOC120094795 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene transmembrane protein 237 Neighboring gene mitochondrial intermembrane space import and assembly protein 40-like Neighboring gene MAGUK p55 scaffold protein 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within calcium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within single fertilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within sperm capacitation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sperm capacitation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle-mediated transport to the plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of CatSper complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm principal piece ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cation channel sperm-associated targeting subunit tau
    Names
    C2 calcium-dependent domain-containing protein 6
    amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11
    amyotrophic lateral sclerosis 2 chromosomal region candidate gene 11 protein
    amyotrophic lateral sclerosis 2 chromosome region, candidate 11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024363.1 → NP_001019534.2  cation channel sperm-associated targeting subunit tau isoform 1

      Status: VALIDATED

      Source sequence(s)
      BC083917
      UniProtKB/TrEMBL
      F7ENY6, Q5XHY2
      Conserved Domains (1) summary
      pfam15729
      Location:129 → 537
      ALS2CR11; Amyotrophic lateral sclerosis 2 candidate 11

    2. NM_001409059.1 → NP_001395988.1  cation channel sperm-associated targeting subunit tau isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I5ZTA5, A0A8I6G3E6
      Related
      ENSRNOP00000078612.1, ENSRNOT00000103146.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      67929069..68024993 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039084092.2 → XP_038940020.1  cation channel sperm-associated targeting subunit tau isoform X1

      Conserved Domains (1) summary
      COG5099
      Location:248 → 682
      COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]

    2. XM_039084093.2 → XP_038940021.1  cation channel sperm-associated targeting subunit tau isoform X2

      Conserved Domains (1) summary
      COG5099
      Location:155 → 589
      COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]

    3. XM_039084094.2 → XP_038940022.1  cation channel sperm-associated targeting subunit tau isoform X2

      Conserved Domains (1) summary
      COG5099
      Location:155 → 589
      COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]

    4. XM_039084095.2 → XP_038940023.1  cation channel sperm-associated targeting subunit tau isoform X4

      Conserved Domains (1) summary
      pfam15729
      Location:129 → 537
      ALS2CR11; Amyotrophic lateral sclerosis 2 candidate 11

    5. XM_017596604.3 → XP_017452093.1  cation channel sperm-associated targeting subunit tau isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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