Slamf8 SLAM family member 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slamf8provided by RGD
Official Full Name: SLAM family member 8provided by RGD
Primary source: RGD:1306263
See related: EnsemblRapid:ENSRNOG00000008736 AllianceGenome:RGD:1306263
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable identical protein binding activity and signaling receptor activity. Predicted to be involved in B-1 B cell lineage commitment; immune response; and regulation of B cell differentiation. Predicted to act upstream of or within several processes, including leukocyte chemotaxis involved in inflammatory response; negative regulation of leukocyte migration; and negative regulation of respiratory burst involved in inflammatory response. Predicted to be located in membrane. Orthologous to human SLAMF8 (SLAM family member 8). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 26.1), Thymus (RPKM 13.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q24

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (87580081..87589941, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (85047729..85057571, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (90967862..90978752, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Upregulation of SLAMF8 aggravates ischemia/reperfusion-induced ferroptosis and injury in cardiomyocyte.
Title: Upregulation of SLAMF8 aggravates ischemia/reperfusion-induced ferroptosis and injury in cardiomyocyte.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in B-1 B cell lineage commitment	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within leukocyte chemotaxis involved in inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of dendritic cell chemotaxis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of macrophage chemotaxis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of monocyte chemotaxis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neutrophil migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of respiratory burst involved in inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phagosome acidification	ISO Inferred from Sequence Orthology more info
involved_in regulation of B cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of NAD(P)H oxidase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of kinase activity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: SLAM family member 8 precursor; SLAM family member 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.