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    Prl3d1 prolactin family 3, subfamily D member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 691552, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Prl3d1provided by RGD
    Official Full Name
    prolactin family 3, subfamily D member 1provided by RGD
    Primary source
    RGD:1582762
    See related
    EnsemblRapid:ENSRNOG00000080988 AllianceGenome:RGD:1582762
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pl-1; rPL-I
    Summary
    Predicted to enable hormone activity and prolactin receptor binding activity. Predicted to be involved in several processes, including female pregnancy; positive regulation of lactation; and positive regulation of receptor signaling pathway via JAK-STAT. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Prl3d1 in Genome Data Viewer
    Location:
    17p12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (38251180..38257209, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (37823027..37829506, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (42849469..42855496, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene prolactin-3D1-like Neighboring gene serine/threonine-protein phosphatase 2A catalytic subunit Neighboring gene prolactin Neighboring gene ribosomal protein L19, pseudogene 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A cDNA encoding a new member of the rat placental lactogen family, PL-I mosaic (PL-Im). Hirosawa M, et al. Endocr J, 1994 Aug. PMID 8528354
    2. Molecular cloning and expression of rat placental lactogen-I complementary deoxyribonucleic acid. Robertson MC, et al. Endocrinology, 1990 Aug. PMID 2373051
    3. Molecular cloning and expression of rat placental lactogen-Iv, a variant of rPL-I present in late pregnant rat placenta. Robertson MC, et al. Endocrinology, 1991 Nov. PMID 1935804
    4. The rat prolactin gene family locus: species-specific gene family expansion. Alam SM, et al. Mamm Genome, 2006 Aug. PMID 16897344
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    prolactin family 3, subfamily D member 1
    Names
    lactogen I
    placental lactogen 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083940.3 → NP_001077409.3  prolactin family 3, subfamily D member 1 precursor

      See identical proteins and their annotated locations for NP_001077409.3

      Status: VALIDATED

      Source sequence(s)
      FQ145043, JAXUCZ010000017
      UniProtKB/TrEMBL
      A0A0U1RVJ1, F1MAB4, Q1KZH8, Q63435
      Related
      ENSRNOP00000060897.4, ENSRNOT00000064243.5
      Conserved Domains (1) summary
      cd10288
      Location:35 → 224
      prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      38251180..38257209 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008771671.3 → XP_008769893.1  prolactin family 3, subfamily D member 1 isoform X1

      UniProtKB/TrEMBL
      Q63435
      Conserved Domains (1) summary
      cd10288
      Location:36 → 225
      prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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